Early Spatial Memory Impairment in a Double Transgenic Model of Alzheimer's Disease TgF-344 AD

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10433295" target="_blank" >RIV/00216208:11140/21:10433295 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9fh.PSq5HX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9fh.PSq5HX</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/brainsci11101300" target="_blank" >10.3390/brainsci11101300</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Early Spatial Memory Impairment in a Double Transgenic Model of Alzheimer's Disease TgF-344 AD

Popis výsledku v původním jazyce

Before the course of Alzheimer&apos;s disease fully manifests itself and largely impairs a patient&apos;s cognitive abilities, its progression has already lasted for a considerable time without being noticed. In this project, we mapped the development of spatial orientation impairment in an active place avoidance task-a highly sensitive test for mild hippocampal damage. We tested vision, anxiety and spatial orientation performance at four age levels of 4, 6, 9, and 12 months across male and female TgF-344 AD rats carrying human genes for presenilin-1 and amyloid precursor protein. We found a progressive deterioration of spatial navigation in transgenic animals, beginning already at the age of 4 months, that fully developed at 6 months of age across both male and female groups, compared to their age-matched controls. In addition, we described the gradual vision impairment that was accentuated in females at the age of 12 months. These results indicate a rather early onset of cognitive impairment in the TgF-344 AD Alzheimer&apos;s disease model, starting earlier than shown to date, and preceding the reported development of amyloid plaques.

Název v anglickém jazyce

Early Spatial Memory Impairment in a Double Transgenic Model of Alzheimer's Disease TgF-344 AD

Popis výsledku anglicky

Before the course of Alzheimer&apos;s disease fully manifests itself and largely impairs a patient&apos;s cognitive abilities, its progression has already lasted for a considerable time without being noticed. In this project, we mapped the development of spatial orientation impairment in an active place avoidance task-a highly sensitive test for mild hippocampal damage. We tested vision, anxiety and spatial orientation performance at four age levels of 4, 6, 9, and 12 months across male and female TgF-344 AD rats carrying human genes for presenilin-1 and amyloid precursor protein. We found a progressive deterioration of spatial navigation in transgenic animals, beginning already at the age of 4 months, that fully developed at 6 months of age across both male and female groups, compared to their age-matched controls. In addition, we described the gradual vision impairment that was accentuated in females at the age of 12 months. These results indicate a rather early onset of cognitive impairment in the TgF-344 AD Alzheimer&apos;s disease model, starting earlier than shown to date, and preceding the reported development of amyloid plaques.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/EF16_019%2F0000787" target="_blank" >EF16_019/0000787: Centrum výzkumu infekčních onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Sciences [online]

ISSN

2076-3425

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

1300

Kód UT WoS článku

000712759600001

EID výsledku v databázi Scopus

2-s2.0-85116165362