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Hyperbaric Oxygen Enhances Collagen III Formation in Wound of ZDF Rat

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10436262" target="_blank" >RIV/00216208:11140/21:10436262 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-FZjDXWjq3" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-FZjDXWjq3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.33549/physiolres.934684" target="_blank" >10.33549/physiolres.934684</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Hyperbaric Oxygen Enhances Collagen III Formation in Wound of ZDF Rat

  • Popis výsledku v původním jazyce

    Diabetic foot ulcer (DFU) is a serious complication of diabetes and hyperbaric oxygen therapy (HBOT) is also considered in comprehensive treatment. The evidence supporting the use of HBOT in DFU treatment is controversial. The aim of this work was to introduce a DFU model in ZDF rat by creating a wound on the back of an animal and to investigate the effect of HBOT on the defect by macroscopic evaluation, quantitative histological evaluation of collagen (types I and III), evaluation of angiogenesis and determination of interleukin 6 (IL6) levels in the plasma. The study included 10 rats in the control group (CONT) and 10 in the HBOT group, who underwent HBOT in standard clinical regimen. Histological evaluation was performed on the 18th day after induction of defect. The results show that HBOT did not affect the macroscopic size of the defect nor IL6 plasma levels. A volume fraction of type I collagen was slightly increased by HBOT without reaching statistical significance (1.35 +/- 0.49 and 1.94 +/- 0.67 %, CONT and HBOT, respectively). In contrast, the collagen type III volume fraction was similar to 120 % higher in HBOT wounds (1.41 +/- 0.81 %) than in CONT ones (0.63 +/- 0.37 %; p=0.046). In addition, the ratio of the volume fraction of both collagens in the wound ((I+III)(w)) to the volume fraction of both collagens in the adjacent healthy skin ((I+III)(h)) was similar to 65 % higher in rats subjected to HBOT (8.9 +/- 3.07 vs. 5.38 +/- 1.86 %, HBOT and CONT, respectively; p=0.028). Vessels density (number per 1 mm(2)) was found to be higher in CONT vs. HBOT (206.5 +/- 41.8 and 124 +/- 28.2, respectively, p&lt;0.001). Our study suggests that HBOT promotes collagen III formation and decreases the number of newly formed vessels at the early phases of healing.

  • Název v anglickém jazyce

    Hyperbaric Oxygen Enhances Collagen III Formation in Wound of ZDF Rat

  • Popis výsledku anglicky

    Diabetic foot ulcer (DFU) is a serious complication of diabetes and hyperbaric oxygen therapy (HBOT) is also considered in comprehensive treatment. The evidence supporting the use of HBOT in DFU treatment is controversial. The aim of this work was to introduce a DFU model in ZDF rat by creating a wound on the back of an animal and to investigate the effect of HBOT on the defect by macroscopic evaluation, quantitative histological evaluation of collagen (types I and III), evaluation of angiogenesis and determination of interleukin 6 (IL6) levels in the plasma. The study included 10 rats in the control group (CONT) and 10 in the HBOT group, who underwent HBOT in standard clinical regimen. Histological evaluation was performed on the 18th day after induction of defect. The results show that HBOT did not affect the macroscopic size of the defect nor IL6 plasma levels. A volume fraction of type I collagen was slightly increased by HBOT without reaching statistical significance (1.35 +/- 0.49 and 1.94 +/- 0.67 %, CONT and HBOT, respectively). In contrast, the collagen type III volume fraction was similar to 120 % higher in HBOT wounds (1.41 +/- 0.81 %) than in CONT ones (0.63 +/- 0.37 %; p=0.046). In addition, the ratio of the volume fraction of both collagens in the wound ((I+III)(w)) to the volume fraction of both collagens in the adjacent healthy skin ((I+III)(h)) was similar to 65 % higher in rats subjected to HBOT (8.9 +/- 3.07 vs. 5.38 +/- 1.86 %, HBOT and CONT, respectively; p=0.028). Vessels density (number per 1 mm(2)) was found to be higher in CONT vs. HBOT (206.5 +/- 41.8 and 124 +/- 28.2, respectively, p&lt;0.001). Our study suggests that HBOT promotes collagen III formation and decreases the number of newly formed vessels at the early phases of healing.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10610 - Biophysics

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Svazek periodika

    70

  • Číslo periodika v rámci svazku

    5

  • Stát vydavatele periodika

    CZ - Česká republika

  • Počet stran výsledku

    12

  • Strana od-do

    787-798

  • Kód UT WoS článku

    000729810300012

  • EID výsledku v databázi Scopus

    2-s2.0-85122305226