Histology of abdominal incisions in rabbit - in vivo experiment with incorporation of PCL and PCL/PVA-based artificial meshes enriched with PRP

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10313899" target="_blank" >RIV/00216208:11140/15:10313899 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Histology of abdominal incisions in rabbit - in vivo experiment with incorporation of PCL and PCL/PVA-based artificial meshes enriched with PRP

Popis výsledku v původním jazyce

Using quantitative histology, the fraction of type I collagen, the fraction of actin-positive myofibroblasts, and the density of CD31-positive microvessel profiles were compared in samples of healing abdominal wall in rabbit. In two groups, the healing was supported by combinations of PCL+PRP or PCL/PVA+PRP artificial tissue-engineered meshes. The third group was healing spontaneously. No quantitative differences in type I collagen fraction, myofibroblasts, or microvessel density were found when comparing all the groups under study. Qualitatively, the incision supported with scaffolds formed a more regularly arranged wound with more equally distributed collagen than found in samples without scaffolds. Under both types of scaffolds, granular connectivetissue with many microvessels and collagen formation was found. The remnants of the PCL+PRP scaffolds showed a better integration of newly formed collagen than the PCL/PVA+PRP scaffolds. However, similar total amounts of collagen were fou

Název v anglickém jazyce

Histology of abdominal incisions in rabbit - in vivo experiment with incorporation of PCL and PCL/PVA-based artificial meshes enriched with PRP

Popis výsledku anglicky

Using quantitative histology, the fraction of type I collagen, the fraction of actin-positive myofibroblasts, and the density of CD31-positive microvessel profiles were compared in samples of healing abdominal wall in rabbit. In two groups, the healing was supported by combinations of PCL+PRP or PCL/PVA+PRP artificial tissue-engineered meshes. The third group was healing spontaneously. No quantitative differences in type I collagen fraction, myofibroblasts, or microvessel density were found when comparing all the groups under study. Qualitatively, the incision supported with scaffolds formed a more regularly arranged wound with more equally distributed collagen than found in samples without scaffolds. Under both types of scaffolds, granular connectivetissue with many microvessels and collagen formation was found. The remnants of the PCL+PRP scaffolds showed a better integration of newly formed collagen than the PCL/PVA+PRP scaffolds. However, similar total amounts of collagen were fou

Druh

V_souhrn - Souhrnná výzkumná zpráva

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

—

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Počet stran výsledku

19

Místo vydání

—

Název nakladatele resp. objednatele

Ústav experimentální medicíny AV ČR, v.v.i.

Verze

—