Histology of ventral abdominal incisions in a porcine model - in vivo experiment with incorporation of artificial meshes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10191822" target="_blank" >RIV/00216208:11140/12:10191822 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Histology of ventral abdominal incisions in a porcine model - in vivo experiment with incorporation of artificial meshes

Popis výsledku v původním jazyce

We examined the tissue reaction to incorporation of two types of artificial tissue-engineered meshes in porcine abdominal wall after 6 and 12 weeks of regeneration. Using six quantitative histological parameters, the area fraction of type I collagen, actin-positive smooth muscle cells and myofibroblasts, and the microvessel density was assessed in the healing incision and 2 cm laterally from the incision. From histological point of view, both types of scaffolds were well and uniformly integrated withinthe collagenous connective tissue of the healing incision. The presence of both types of scaffolds led to increased amount of contractile myofibroblasts within the healing incision, but the amount of microvessels in samples with scaffolds was comparablewith samples without scaffolds. In one of these scaffolds, the microvessel density was positively correlated with the fraction of type I collagen.

Název v anglickém jazyce

Histology of ventral abdominal incisions in a porcine model - in vivo experiment with incorporation of artificial meshes

Popis výsledku anglicky

We examined the tissue reaction to incorporation of two types of artificial tissue-engineered meshes in porcine abdominal wall after 6 and 12 weeks of regeneration. Using six quantitative histological parameters, the area fraction of type I collagen, actin-positive smooth muscle cells and myofibroblasts, and the microvessel density was assessed in the healing incision and 2 cm laterally from the incision. From histological point of view, both types of scaffolds were well and uniformly integrated withinthe collagenous connective tissue of the healing incision. The presence of both types of scaffolds led to increased amount of contractile myofibroblasts within the healing incision, but the amount of microvessels in samples with scaffolds was comparablewith samples without scaffolds. In one of these scaffolds, the microvessel density was positively correlated with the fraction of type I collagen.

Druh

V_souhrn - Souhrnná výzkumná zpráva

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

Počet stran výsledku

19

Místo vydání

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Název nakladatele resp. objednatele

CB Bio s.r.o.

Verze

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