Mitochondria in Human Reproduction: Novel Paradigm in the Onset of Neurodegenerative Disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F23%3A10462144" target="_blank" >RIV/00216208:11140/23:10462144 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TRSOMhBZ-_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TRSOMhBZ-_</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934982" target="_blank" >10.33549/physiolres.934982</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondria in Human Reproduction: Novel Paradigm in the Onset of Neurodegenerative Disorders

Popis výsledku v původním jazyce

The disease progression of neurodegenerative disorders (NDD), including Alzheimer&apos;s, Parkinson&apos;s and Huntington&apos;s disease, is inextricably tied to mitochondrial dysfunction. However, although the contribution by nuclear gene mutations is recognised for familial onset of NDD, the degree to which cytoplasmic inheritance serves as a predetermining factor for the predisposition and onset of NDD is not yet fully understood. We review the reproductive mechanisms responsible for ensuring a healthy mitochondrial population within each new generation and elucidate how advanced maternal age can constitute an increased risk for the onset of NDD in the offspring, through the increased heteroplasmic burden. On the one hand, this review draws attention to how assisted reproductive technologies (ART) can impair mitochondrial fitness in offspring. On the other hand, we consider qualified ART approaches as a significant tool for the prevention of NDD pathogenesis.

Název v anglickém jazyce

Mitochondria in Human Reproduction: Novel Paradigm in the Onset of Neurodegenerative Disorders

Popis výsledku anglicky

The disease progression of neurodegenerative disorders (NDD), including Alzheimer&apos;s, Parkinson&apos;s and Huntington&apos;s disease, is inextricably tied to mitochondrial dysfunction. However, although the contribution by nuclear gene mutations is recognised for familial onset of NDD, the degree to which cytoplasmic inheritance serves as a predetermining factor for the predisposition and onset of NDD is not yet fully understood. We review the reproductive mechanisms responsible for ensuring a healthy mitochondrial population within each new generation and elucidate how advanced maternal age can constitute an increased risk for the onset of NDD in the offspring, through the increased heteroplasmic burden. On the one hand, this review draws attention to how assisted reproductive technologies (ART) can impair mitochondrial fitness in offspring. On the other hand, we consider qualified ART approaches as a significant tool for the prevention of NDD pathogenesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

1802-9973

Svazek periodika

72

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

12

Strana od-do

137-148

Kód UT WoS článku

001057117900002

EID výsledku v databázi Scopus

2-s2.0-85158147454