Expression profiles in viral responsive genes in oral and oropharyngeal cancers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10070590" target="_blank" >RIV/00216208:11150/10:10070590 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression profiles in viral responsive genes in oral and oropharyngeal cancers

Popis výsledku v původním jazyce

The association between Human Papillomavirus (HPV) DNA and oropharyngeal squamous cell carcinoma (SCC) has been supported by numerous studies strongly implicating HPV infection as a factor in the development of this cancer. In contrast, squamous cell carcinoma of the oral cavity has not been associated with HPV DNA, suggesting alternate aetiologic factors. Quantitative polymerace chain reaction (qPCR) studies to compare the expression levels of genes that may act as indicators of persistent stimulationby viral antigen in both oral cavity and oropharyngeal squamous cell cancers was done. Results demonstrate that HPV-positive oropharyngeal tumours displayed gene expression patterns indicative of a viral signature and that HPVnegative oropharyngeal tumours do not display similar expression patterns. No evidence of either a viral or bacterial signature in the oral tumours was found.10.1016/j.ejca.2010.01.026

Název v anglickém jazyce

Expression profiles in viral responsive genes in oral and oropharyngeal cancers

Popis výsledku anglicky

The association between Human Papillomavirus (HPV) DNA and oropharyngeal squamous cell carcinoma (SCC) has been supported by numerous studies strongly implicating HPV infection as a factor in the development of this cancer. In contrast, squamous cell carcinoma of the oral cavity has not been associated with HPV DNA, suggesting alternate aetiologic factors. Quantitative polymerace chain reaction (qPCR) studies to compare the expression levels of genes that may act as indicators of persistent stimulationby viral antigen in both oral cavity and oropharyngeal squamous cell cancers was done. Results demonstrate that HPV-positive oropharyngeal tumours displayed gene expression patterns indicative of a viral signature and that HPVnegative oropharyngeal tumours do not display similar expression patterns. No evidence of either a viral or bacterial signature in the oral tumours was found.10.1016/j.ejca.2010.01.026

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Cancer

ISSN

0959-8049

e-ISSN

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Svazek periodika

46

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000277812400026

EID výsledku v databázi Scopus

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