Bioinformatics analysis of immune characteristics in tumors with alternative tumorigenesis pathways associated with human papillomaviruses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10454399" target="_blank" >RIV/00216208:11310/22:10454399 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/37" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/37</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bioinformatics analysis of immune characteristics in tumors with alternative tumorigenesis pathways associated with human papillomaviruses

Popis výsledku v původním jazyce

Human papillomaviruses induce a subset of head and neck squamous cell carcinomas and anogenital cancers, particularly cervical cancer. The main viral proteins that contribute to tumorigenesis are the E6 and E7 oncoproteins, the expression of which is usually enhanced after the integration of viral DNA into the host genome. Recently, an alternative tumorigenesis pathway characterized by extrachromosomal HPV persistence and increased expression of the viral E2, E4, and E5 genes has been suggested. As an antitumor immune response is a crucial factor in the prognosis of HPV-driven cancers, we performed bioinformatics analysis of immune characteristics of HPV-dependent tumors and their association with types of tumorigenesis. Expression or immune-related genes, tumor-infiltrating immune cells, and overall survival were evaluated.

Název v anglickém jazyce

Bioinformatics analysis of immune characteristics in tumors with alternative tumorigenesis pathways associated with human papillomaviruses

Popis výsledku anglicky

Human papillomaviruses induce a subset of head and neck squamous cell carcinomas and anogenital cancers, particularly cervical cancer. The main viral proteins that contribute to tumorigenesis are the E6 and E7 oncoproteins, the expression of which is usually enhanced after the integration of viral DNA into the host genome. Recently, an alternative tumorigenesis pathway characterized by extrachromosomal HPV persistence and increased expression of the viral E2, E4, and E5 genes has been suggested. As an antitumor immune response is a crucial factor in the prognosis of HPV-driven cancers, we performed bioinformatics analysis of immune characteristics of HPV-dependent tumors and their association with types of tumorigenesis. Expression or immune-related genes, tumor-infiltrating immune cells, and overall survival were evaluated.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů