Can the type of oncogenic transformation by human papillomaviruses influence the choice of cancer immunotherapy?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10470056" target="_blank" >RIV/00216208:11310/23:10470056 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/41/" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/41/</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Can the type of oncogenic transformation by human papillomaviruses influence the choice of cancer immunotherapy?

Popis výsledku v původním jazyce

High-risk human papillomaviruses can induce malignant transformation of cells resulting in anogenital cancers, particularly cervical cancer (CC), and a proportion of head and neck squamous cell carcinomas (HNSCC). The viral E6 and E7 oncoproteins are required for the induction and maintenance of transformation and the E5 protein contributes to tumorigenesis (1). The E6 and E7 expression is usually increased after the integration ofviral DNAinto the host genome which is associated with inactivation of the viral E2 gene (2). InHNSCC and CC cases driven by HPV infection, analternative tumorigenesis pathway has been described with extrachromosomal persistence of the HPV genome and higher expression of the viral E2, E4,and E5 genes (3).

Název v anglickém jazyce

Can the type of oncogenic transformation by human papillomaviruses influence the choice of cancer immunotherapy?

Popis výsledku anglicky

High-risk human papillomaviruses can induce malignant transformation of cells resulting in anogenital cancers, particularly cervical cancer (CC), and a proportion of head and neck squamous cell carcinomas (HNSCC). The viral E6 and E7 oncoproteins are required for the induction and maintenance of transformation and the E5 protein contributes to tumorigenesis (1). The E6 and E7 expression is usually increased after the integration ofviral DNAinto the host genome which is associated with inactivation of the viral E2 gene (2). InHNSCC and CC cases driven by HPV infection, analternative tumorigenesis pathway has been described with extrachromosomal persistence of the HPV genome and higher expression of the viral E2, E4,and E5 genes (3).

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů