The effect of chronic iron losses on liver regeneration in male and female rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10072332" target="_blank" >RIV/00216208:11150/10:10072332 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/10:10072332

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effect of chronic iron losses on liver regeneration in male and female rats

Popis výsledku v původním jazyce

We studied the effect of iron deficiency on liver regeneration and innate immunity - respiratory burst of PMN. Wistar rats, males (M) and females (F) had sham withdrawals or males (M-w) and females (F-w) had nine blood withdrawals every week. All rats were sacrificed in 10th week after 67% hepatectomy (PH). We determined blood cell count, respiratory burst (RB), serum prohepcidin, estradiol, iron, iron binding capacity (TIBC) and liver iron stores. Both genders with blood withdrawals had early beginningof liver regeneration after PH. The preconditioning (withdrawals) leads to increase in iron turnover and stores following best reactivity of PMN, rapid decrease in serum prohepcidin, and early initiation of liver regeneration, mainly in females. Femaleshave higher iron turnover, liver iron stores more easily mobilized for blood losses, because next gravidity physiologically begin immediately after birth.

Název v anglickém jazyce

The effect of chronic iron losses on liver regeneration in male and female rats

Popis výsledku anglicky

We studied the effect of iron deficiency on liver regeneration and innate immunity - respiratory burst of PMN. Wistar rats, males (M) and females (F) had sham withdrawals or males (M-w) and females (F-w) had nine blood withdrawals every week. All rats were sacrificed in 10th week after 67% hepatectomy (PH). We determined blood cell count, respiratory burst (RB), serum prohepcidin, estradiol, iron, iron binding capacity (TIBC) and liver iron stores. Both genders with blood withdrawals had early beginningof liver regeneration after PH. The preconditioning (withdrawals) leads to increase in iron turnover and stores following best reactivity of PMN, rapid decrease in serum prohepcidin, and early initiation of liver regeneration, mainly in females. Femaleshave higher iron turnover, liver iron stores more easily mobilized for blood losses, because next gravidity physiologically begin immediately after birth.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, CzechoSK

ISSN

1213-8118

e-ISSN

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Svazek periodika

154

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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