Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10105393" target="_blank" >RIV/00216208:11150/11:10105393 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0024320511003997" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0024320511003997</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.lfs.2011.08.002" target="_blank" >10.1016/j.lfs.2011.08.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration

Popis výsledku v původním jazyce

The aim of the study was to investigate whether low doses of erythropoietin (EPO) can stimulate liver regeneration after partial hepatectomy. Parameters of liver regeneration were assessed 3 days after 70% hepatectomy by means of immunochemistry and proteomics. EPO was given twice in low dosages (200 and 600 IU/kg BW). We showed that EPO facilitated hepatic regeneration in rats. Enhanced hepatocyte proliferation (Ki67, BrdU-positive cells) was observed in all EPO-treated groups. By performing differential proteomic analysis, we identified two proteins which resulted sensitive to EPO treatment after hepatectomy: Peroxiredoxin-1 and glutathione S-transferase Mu 1.

Název v anglickém jazyce

Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration

Popis výsledku anglicky

The aim of the study was to investigate whether low doses of erythropoietin (EPO) can stimulate liver regeneration after partial hepatectomy. Parameters of liver regeneration were assessed 3 days after 70% hepatectomy by means of immunochemistry and proteomics. EPO was given twice in low dosages (200 and 600 IU/kg BW). We showed that EPO facilitated hepatic regeneration in rats. Enhanced hepatocyte proliferation (Ki67, BrdU-positive cells) was observed in all EPO-treated groups. By performing differential proteomic analysis, we identified two proteins which resulted sensitive to EPO treatment after hepatectomy: Peroxiredoxin-1 and glutathione S-transferase Mu 1.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Life Sciences

ISSN

0024-3205

e-ISSN

—

Svazek periodika

89

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

827-833

Kód UT WoS článku

000297486100001

EID výsledku v databázi Scopus

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