Activation of TGF-beta Receptors and Smad Proteins by Atorvastatin is Related to Reduced Atherogenesis in ApoE/LDLR Double Knockout Mice
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10124885" target="_blank" >RIV/00216208:11150/12:10124885 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11160/12:10124885
Výsledek na webu
<a href="https://www.jstage.jst.go.jp/article/jat/19/2/19_8185/_pdf" target="_blank" >https://www.jstage.jst.go.jp/article/jat/19/2/19_8185/_pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5551/jat.8185" target="_blank" >10.5551/jat.8185</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Activation of TGF-beta Receptors and Smad Proteins by Atorvastatin is Related to Reduced Atherogenesis in ApoE/LDLR Double Knockout Mice
Popis výsledku v původním jazyce
Aim: Transforming growth factor-beta (TGF-beta) plays important role in atherogenesis via TGF-beta receptors and Smad proteins, which determine its signaling activity. In this study, we hypothesized, whether non-lipid related effects of atorvastatin, affect both endoglin/ALK-5/Smad2/eNOS and/or endoglin/ALK-1/Smad1/VEGF previously proposed pathways in ApoE/LDLR double knockout mice. Methods: ApoE/LDLR double knockout mice were divided into two groups. The chow group (CHOW) (n = 8) was fed with chow diet, while in the atorvastatin group (ATV) (n = 8) atorvastatin was added to the chow diet at dose 50 mg/kg/day. Biochemical analyses of lipid profile, lesion area measurement, immunohistochemistry and Western blot analysis of endoglin, ALK-1, 5, phosphorylated and non-phosphorylated forms Smad-1, 2, VEGF and eNOS proteins in mice aorta were performed. Results: Biochemical analysis of blood serum and morphometric analysis of aortic lesion size showed that atorvastatin treatment resulted in
Název v anglickém jazyce
Activation of TGF-beta Receptors and Smad Proteins by Atorvastatin is Related to Reduced Atherogenesis in ApoE/LDLR Double Knockout Mice
Popis výsledku anglicky
Aim: Transforming growth factor-beta (TGF-beta) plays important role in atherogenesis via TGF-beta receptors and Smad proteins, which determine its signaling activity. In this study, we hypothesized, whether non-lipid related effects of atorvastatin, affect both endoglin/ALK-5/Smad2/eNOS and/or endoglin/ALK-1/Smad1/VEGF previously proposed pathways in ApoE/LDLR double knockout mice. Methods: ApoE/LDLR double knockout mice were divided into two groups. The chow group (CHOW) (n = 8) was fed with chow diet, while in the atorvastatin group (ATV) (n = 8) atorvastatin was added to the chow diet at dose 50 mg/kg/day. Biochemical analyses of lipid profile, lesion area measurement, immunohistochemistry and Western blot analysis of endoglin, ALK-1, 5, phosphorylated and non-phosphorylated forms Smad-1, 2, VEGF and eNOS proteins in mice aorta were performed. Results: Biochemical analysis of blood serum and morphometric analysis of aortic lesion size showed that atorvastatin treatment resulted in
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of atherosclerosis and thrombosis
ISSN
1340-3478
e-ISSN
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Svazek periodika
19
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
JP - Japonsko
Počet stran výsledku
12
Strana od-do
115-126
Kód UT WoS článku
000301282500002
EID výsledku v databázi Scopus
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