Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F13%3A10190725" target="_blank" >RIV/00216208:11150/13:10190725 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/62/62_S135.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/62/62_S135.pdf</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension

Popis výsledku v původním jazyce

Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or captopril can prevent these potential alterations. In a six-week experiment, Wistar rats were divided into 4 groups: controls, rats exposed to continuous light (LC), LC + captopril (100 mg/kg/24 h) and LC + melatonin (10 mg/kg/24h). We conclude that in continuous light-induced hypertension, administration of melatonin, along with SBP reduction, decreases collagen I and III concentration in the aorta. It is suggested that antifibrotic effect of melatonin may reduce the stiffnessof the aorta and small arteries and beneficially influence the peripheral vascular resistance.

Název v anglickém jazyce

Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension

Popis výsledku anglicky

Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or captopril can prevent these potential alterations. In a six-week experiment, Wistar rats were divided into 4 groups: controls, rats exposed to continuous light (LC), LC + captopril (100 mg/kg/24 h) and LC + melatonin (10 mg/kg/24h). We conclude that in continuous light-induced hypertension, administration of melatonin, along with SBP reduction, decreases collagen I and III concentration in the aorta. It is suggested that antifibrotic effect of melatonin may reduce the stiffnessof the aorta and small arteries and beneficially influence the peripheral vascular resistance.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

—

Svazek periodika

62

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

"S135"-"S141"

Kód UT WoS článku

000328901900015

EID výsledku v databázi Scopus

—