Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271858" target="_blank" >RIV/00216208:11150/14:10271858 - isvavai.cz</a>

Výsledek na webu

<a href="http://http:/dx.doi.org/10.1155/2014/703175" target="_blank" >http://http:/dx.doi.org/10.1155/2014/703175</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/703175" target="_blank" >10.1155/2014/703175</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin

Popis výsledku v původním jazyce

Exposure of rats to continuous light attenuates melatonin production and results in hypertension development. This study investigated whether hypertension induced by continuous light (24 hours/day) exposure induces heart and aorta remodelling and if these alterations are prevented by melatonin or angiotensin converting enzyme inhibitor captopril. Exposure to continuous light led to hypertension, LV hypertrophy and fibrosis, and enhancement of the oxidative load in the LV and aorta. Increase in systolicblood pressure by continuous light exposure was prevented completely by captopril and partially by melatonin. Both captopril and melatonin reduced the wall thickness and cross-sectional area of the aorta and reduced the level of oxidative stress. However, only captopril reduced LV hypertrophy and only melatonin reduced LV hydroxyproline concentration.

Název v anglickém jazyce

Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin

Popis výsledku anglicky

Exposure of rats to continuous light attenuates melatonin production and results in hypertension development. This study investigated whether hypertension induced by continuous light (24 hours/day) exposure induces heart and aorta remodelling and if these alterations are prevented by melatonin or angiotensin converting enzyme inhibitor captopril. Exposure to continuous light led to hypertension, LV hypertrophy and fibrosis, and enhancement of the oxidative load in the LV and aorta. Increase in systolicblood pressure by continuous light exposure was prevented completely by captopril and partially by melatonin. Both captopril and melatonin reduced the wall thickness and cross-sectional area of the aorta and reduced the level of oxidative stress. However, only captopril reduced LV hypertrophy and only melatonin reduced LV hydroxyproline concentration.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

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Svazek periodika

2014

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000339214100001

EID výsledku v databázi Scopus

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