Single- and multiple-dose pharmacokinetics of arginase inhibitor N-omega-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10140109" target="_blank" >RIV/00216208:11150/14:10140109 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.4149/gpb_2013078" target="_blank" >http://dx.doi.org/10.4149/gpb_2013078</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/gpb_2013078" target="_blank" >10.4149/gpb_2013078</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Single- and multiple-dose pharmacokinetics of arginase inhibitor N-omega-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats

Popis výsledku v původním jazyce

Arginase inhibitor N-?-hydroxy-nor-L-arginine (nor-NOHA) augments synthesis of nitric oxide (NO) exerting therapeutic effects in rodent models for cardiovascular and airway diseases. This study examined single- and multiple-dose pharmacokinetics and effects of nor NOHA on plasma amino acids in Wistar rats. Animals were administered 30 mg/kg nor NOHA in a single bolus intravenous (i.v.) or intraperitoneal (i.p.) injection, or five once-daily i.p. injections at the same dose, or vehicle. Nor-NOHA and amino acids were assayed in blood plasma by high-performance liquid chromatography. After a bolus i.v. injection, the elimination of nor-NOHA was rapid (the mean residence time=12.5 min). The area under the concentration-time curve and maximum concentrationwere higher by 17% and 31%, respectively, after the fifth as compared to the first i.p. injection. A shift in arginine utilization towards the synthesis of NO was indicated by elevated citrulline-to-ornithine and citrulline-to-arginine ra

Název v anglickém jazyce

Single- and multiple-dose pharmacokinetics of arginase inhibitor N-omega-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats

Popis výsledku anglicky

Arginase inhibitor N-?-hydroxy-nor-L-arginine (nor-NOHA) augments synthesis of nitric oxide (NO) exerting therapeutic effects in rodent models for cardiovascular and airway diseases. This study examined single- and multiple-dose pharmacokinetics and effects of nor NOHA on plasma amino acids in Wistar rats. Animals were administered 30 mg/kg nor NOHA in a single bolus intravenous (i.v.) or intraperitoneal (i.p.) injection, or five once-daily i.p. injections at the same dose, or vehicle. Nor-NOHA and amino acids were assayed in blood plasma by high-performance liquid chromatography. After a bolus i.v. injection, the elimination of nor-NOHA was rapid (the mean residence time=12.5 min). The area under the concentration-time curve and maximum concentrationwere higher by 17% and 31%, respectively, after the fifth as compared to the first i.p. injection. A shift in arginine utilization towards the synthesis of NO was indicated by elevated citrulline-to-ornithine and citrulline-to-arginine ra

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0022" target="_blank" >EE2.3.30.0022: Podpora vytváření, rozvoje a mobility kvalitních výzkumně-vývojových týmů na Univerzitě Karlově</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

10

Strana od-do

189-198

Kód UT WoS článku

000336512200005

EID výsledku v databázi Scopus

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