Doxorubicin-induced behavioral disturbances in rats: Protective effect of melatonin and captopril

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10271860" target="_blank" >RIV/00216208:11150/14:10271860 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.pbb.2014.06.021" target="_blank" >http://dx.doi.org/10.1016/j.pbb.2014.06.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pbb.2014.06.021" target="_blank" >10.1016/j.pbb.2014.06.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Doxorubicin-induced behavioral disturbances in rats: Protective effect of melatonin and captopril

Popis výsledku v původním jazyce

Doxorubicin is a recognized chemotherapeutic agent widely employed in human malignancies. The aim of this work was to show, whether administration of doxorubicin could induce behavioral disturbances in rats, and whether angiotensin-converting enzyme inhibitor captopril or melatonin can modify these potential alterations. Doxorubicin increased significantly systolic blood pressure and parameters of oxidative stress. Moreover, doxorubicin enhanced the level of anxiety in the tests of OF, EPM, and LDB. Captopril and melatonin prevented the blood pressure rise and the enhancement of oxidative load. Importantly, both substances reduced the parameters of anxiety. It does not seem unreasonable to suppose that this protective effect of captopril or melatonin against anxiety development might have been related to the antioxidative effects of both substances.

Název v anglickém jazyce

Doxorubicin-induced behavioral disturbances in rats: Protective effect of melatonin and captopril

Popis výsledku anglicky

Doxorubicin is a recognized chemotherapeutic agent widely employed in human malignancies. The aim of this work was to show, whether administration of doxorubicin could induce behavioral disturbances in rats, and whether angiotensin-converting enzyme inhibitor captopril or melatonin can modify these potential alterations. Doxorubicin increased significantly systolic blood pressure and parameters of oxidative stress. Moreover, doxorubicin enhanced the level of anxiety in the tests of OF, EPM, and LDB. Captopril and melatonin prevented the blood pressure rise and the enhancement of oxidative load. Importantly, both substances reduced the parameters of anxiety. It does not seem unreasonable to suppose that this protective effect of captopril or melatonin against anxiety development might have been related to the antioxidative effects of both substances.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmacology, Biochemistry &amp; Behavior

ISSN

0091-3057

e-ISSN

—

Svazek periodika

124

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

284-289

Kód UT WoS článku

000343621900040

EID výsledku v databázi Scopus

—