Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10281586" target="_blank" >RIV/00216208:11150/14:10281586 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61389030:_____/14:00432566 RIV/00216208:11160/14:10281586
Výsledek na webu
<a href="http://www.sciencedirect.com/science/article/pii/S0926669014002210" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0926669014002210</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.indcrop.2014.04.018" target="_blank" >10.1016/j.indcrop.2014.04.018</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines
Popis výsledku v původním jazyce
The leaves of Myrica rubra (Sieb. et Zucc), a subtropical Asian fruit tree with traditional use in folk medicines, were extracted by hydrodistillation. The antiproliferative effect of obtained M. rubra essential oil (MEO) was tested in human colon and ileocecal adenocarcinoma cell lines HCT8, SW620, SW480, HT29 and Caco2. Cytostatic drug paclitaxel was used as a positive control. MEO significantly inhibited cell proliferation in concentration-dependent manner in all cell lines. The efficacy of ME differed in individual cell lines, with Caco2 being the most sensitive. In these cells, MEO, IC50 value of 1.5 ?g/mL was obtained using xCelligence system for real-time cell monitoring. In cancer cells, MEO induces apoptosis and caused significant increase ofactivities of initiator as well as effector caspases. Contrary to cancer cells, MEO) did not affect viability of isolated hepatocytes (as a model of normal non-cancerous cells). GC x GC-TOFMS analysis of MEO, chemical composition revealed
Název v anglickém jazyce
Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines
Popis výsledku anglicky
The leaves of Myrica rubra (Sieb. et Zucc), a subtropical Asian fruit tree with traditional use in folk medicines, were extracted by hydrodistillation. The antiproliferative effect of obtained M. rubra essential oil (MEO) was tested in human colon and ileocecal adenocarcinoma cell lines HCT8, SW620, SW480, HT29 and Caco2. Cytostatic drug paclitaxel was used as a positive control. MEO significantly inhibited cell proliferation in concentration-dependent manner in all cell lines. The efficacy of ME differed in individual cell lines, with Caco2 being the most sensitive. In these cells, MEO, IC50 value of 1.5 ?g/mL was obtained using xCelligence system for real-time cell monitoring. In cancer cells, MEO induces apoptosis and caused significant increase ofactivities of initiator as well as effector caspases. Contrary to cancer cells, MEO) did not affect viability of isolated hepatocytes (as a model of normal non-cancerous cells). GC x GC-TOFMS analysis of MEO, chemical composition revealed
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Industrial Crops and Products
ISSN
0926-6690
e-ISSN
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Svazek periodika
59
Číslo periodika v rámci svazku
August
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
20-26
Kód UT WoS článku
000339600400004
EID výsledku v databázi Scopus
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