Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10294842" target="_blank" >RIV/00216208:11150/15:10294842 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10294842

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358648/pdf/ndt-11-619.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358648/pdf/ndt-11-619.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S80746" target="_blank" >10.2147/NDT.S80746</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia

Popis výsledku v původním jazyce

Background: Encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDA-R) is classified as an autoimmune disorder with psychotic symptoms, which are frequently domi-nant. However, it remains unclear how frequently NMDA-R antibodies lead toa condition that mimics psychosis and first-episode schizophrenia. In our work, we investigated the presence of antibodies against NMDA-R in patients with first-episode psychosis (FEP) in comparison with healthy volunteers. Methods: This study included 50 antipsychotic-na?ve patients with FEP (including 21 women) and 50 healthy volunteers (including 21 women). The mean age of the patients was 27.4 (+-7.4) years and that of the healthy controls was 27.0 (+-7.3) years. Antibodies against NMDA-R in the serum were detected by immunofluorescence. Results: None of the investigated patients with an FEP and none of the healthy controls showed positive antibodies against NMDA-Rs. Conclusion: According to results of studies, a small proportion of

Název v anglickém jazyce

Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia

Popis výsledku anglicky

Background: Encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDA-R) is classified as an autoimmune disorder with psychotic symptoms, which are frequently domi-nant. However, it remains unclear how frequently NMDA-R antibodies lead toa condition that mimics psychosis and first-episode schizophrenia. In our work, we investigated the presence of antibodies against NMDA-R in patients with first-episode psychosis (FEP) in comparison with healthy volunteers. Methods: This study included 50 antipsychotic-na?ve patients with FEP (including 21 women) and 50 healthy volunteers (including 21 women). The mean age of the patients was 27.4 (+-7.4) years and that of the healthy controls was 27.0 (+-7.3) years. Antibodies against NMDA-R in the serum were detected by immunofluorescence. Results: None of the investigated patients with an FEP and none of the healthy controls showed positive antibodies against NMDA-Rs. Conclusion: According to results of studies, a small proportion of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuropsychiatric Disease and Treatment

ISSN

1178-2021

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

2015

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

5

Strana od-do

619-623

Kód UT WoS článku

000350606700002

EID výsledku v databázi Scopus

2-s2.0-84929149119