Enhanced Glutamine Availability Exerts Different Effects on Protein and Amino Acid Metabolism in Skeletal Muscle From Healthy and Septic Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10296691" target="_blank" >RIV/00216208:11150/15:10296691 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18450/15:50002555

Výsledek na webu

<a href="http://pen.sagepub.com/content/39/7/847.full.pdf+html" target="_blank" >http://pen.sagepub.com/content/39/7/847.full.pdf+html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0148607114537832" target="_blank" >10.1177/0148607114537832</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enhanced Glutamine Availability Exerts Different Effects on Protein and Amino Acid Metabolism in Skeletal Muscle From Healthy and Septic Rats

Popis výsledku v původním jazyce

The aim of this study was to assess the effect of enhanced extracellular concentration of glutamine (GLN) on leucine oxidation, amino acid concentrations, and protein metabolism in skeletal muscle of intact, laparotomized, and septic rats. Cecal ligationand puncture was used as a model of sepsis. It is concluded that muscles with higher proportion of white fibers are more sensitive to septic stimuli than muscles with higher proportion of red fibers and that enhanced GLN availability exerts different effects on skeletal muscle in septic and healthy conditions. In sepsis may enhanced GLN availability correct GLN deficiency, inhibit BCAA catabolism and exert favorable effect on protein synthesis. In healthy state may enhanced GLN availability lead to severe alterations in intramuscular concentration of a number of amino acids and impair protein synthesis.

Název v anglickém jazyce

Enhanced Glutamine Availability Exerts Different Effects on Protein and Amino Acid Metabolism in Skeletal Muscle From Healthy and Septic Rats

Popis výsledku anglicky

The aim of this study was to assess the effect of enhanced extracellular concentration of glutamine (GLN) on leucine oxidation, amino acid concentrations, and protein metabolism in skeletal muscle of intact, laparotomized, and septic rats. Cecal ligationand puncture was used as a model of sepsis. It is concluded that muscles with higher proportion of white fibers are more sensitive to septic stimuli than muscles with higher proportion of red fibers and that enhanced GLN availability exerts different effects on skeletal muscle in septic and healthy conditions. In sepsis may enhanced GLN availability correct GLN deficiency, inhibit BCAA catabolism and exert favorable effect on protein synthesis. In healthy state may enhanced GLN availability lead to severe alterations in intramuscular concentration of a number of amino acids and impair protein synthesis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Parenteral and Enteral Nutrition

ISSN

0148-6071

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

847-854

Kód UT WoS článku

000360413700012

EID výsledku v databázi Scopus

2-s2.0-84939635650