Potential Anti-cancer Drugs Commonly Used for Other Indications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312036" target="_blank" >RIV/00216208:11150/15:10312036 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/15:10312036

Výsledek na webu

<a href="http://benthamscience.com/journals/current-cancer-drug-targets/volume/15/issue/1/page/35/" target="_blank" >http://benthamscience.com/journals/current-cancer-drug-targets/volume/15/issue/1/page/35/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1568009615666141229152812" target="_blank" >10.2174/1568009615666141229152812</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Potential Anti-cancer Drugs Commonly Used for Other Indications

Popis výsledku v původním jazyce

An increasing resistance of mammalian tumor cells to chemotherapy along with the severe side effects of commonly used cytostatics has raised the urgency in the search for new anti-cancer agents. Several drugs originally approved for indications other than cancer treatment have recently been found to have a cytostatic effect on cancer cells. These drugs could be expediently repurposed as anti-cancer agents, since they have already been tested for toxicity in humans and animals. The groups of newly recognized potential cytostatics discussed in this review include benzimidazole anthelmintics (albendazole, mebendazole, flubendazole), anti-hypertensive drugs (doxazosin, propranolol), psychopharmaceuticals (chlorpromazine, clomipramine) and antidiabetic drugs (metformin, pioglitazone). All these drugs have a definite potential to be used especially in combinations with other cytostatics; the chemotherapy targeting of multiple sites now represents a promising approach in cancer treatment. The

Název v anglickém jazyce

Potential Anti-cancer Drugs Commonly Used for Other Indications

Popis výsledku anglicky

An increasing resistance of mammalian tumor cells to chemotherapy along with the severe side effects of commonly used cytostatics has raised the urgency in the search for new anti-cancer agents. Several drugs originally approved for indications other than cancer treatment have recently been found to have a cytostatic effect on cancer cells. These drugs could be expediently repurposed as anti-cancer agents, since they have already been tested for toxicity in humans and animals. The groups of newly recognized potential cytostatics discussed in this review include benzimidazole anthelmintics (albendazole, mebendazole, flubendazole), anti-hypertensive drugs (doxazosin, propranolol), psychopharmaceuticals (chlorpromazine, clomipramine) and antidiabetic drugs (metformin, pioglitazone). All these drugs have a definite potential to be used especially in combinations with other cytostatics; the chemotherapy targeting of multiple sites now represents a promising approach in cancer treatment. The

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/EE2.3.30.0022" target="_blank" >EE2.3.30.0022: Podpora vytváření, rozvoje a mobility kvalitních výzkumně-vývojových týmů na Univerzitě Karlově</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Cancer Drug Targets

ISSN

1568-0096

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

18

Strana od-do

35-52

Kód UT WoS článku

000350280500005

EID výsledku v databázi Scopus

2-s2.0-84924856986