Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2 '-bipyridines and 4,5-diazafluoren-9-one

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10313730" target="_blank" >RIV/00216208:11150/15:10313730 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216275:25310/15:39899625

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ica.2014.12.021" target="_blank" >http://dx.doi.org/10.1016/j.ica.2014.12.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ica.2014.12.021" target="_blank" >10.1016/j.ica.2014.12.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2 '-bipyridines and 4,5-diazafluoren-9-one

Popis výsledku v původním jazyce

This study describes the synthesis of vanadocene compounds [Cp'2V(L)][OTf]2, where Cp' is substituted cyclopentadienyl ring and L is N,N-chelating ligand. All prepared compounds were characterized by analytical and spectroscopic methods. The structures of [(?5-C5H4Me)2V(bpy)][OTf]2, [(?5-C5H4iPr)2V(bpy)][OTf]2.CH2Cl2, [Cp2V(4,4'-Me2-bpy)][OTf]2, [Cp2V{4,4'-(MeO)2-bpy}][OTf]2.MeOH and [(?5-C5H4Me)2V(dafone)][OTf]2 were further confirmed by the X-ray diffraction analysis. The cytotoxicity study, performedon human leukemia cells MOLT-4 and HL-60, demonstrates that the activity of the vanadocene complexes strongly depends on the nature of the coordinated chelating ligand. The high cytotoxicity was observed for the complex bearing 2,2'-bipyridine, [(?5-C5H4Me)2V(bpy)][OTf]2, that shows IC50 values close to the data observed for cisplatin.

Název v anglickém jazyce

Synthesis, characterization and cytotoxic effect of vanadocene complexes bearing substituted 2,2 '-bipyridines and 4,5-diazafluoren-9-one

Popis výsledku anglicky

This study describes the synthesis of vanadocene compounds [Cp'2V(L)][OTf]2, where Cp' is substituted cyclopentadienyl ring and L is N,N-chelating ligand. All prepared compounds were characterized by analytical and spectroscopic methods. The structures of [(?5-C5H4Me)2V(bpy)][OTf]2, [(?5-C5H4iPr)2V(bpy)][OTf]2.CH2Cl2, [Cp2V(4,4'-Me2-bpy)][OTf]2, [Cp2V{4,4'-(MeO)2-bpy}][OTf]2.MeOH and [(?5-C5H4Me)2V(dafone)][OTf]2 were further confirmed by the X-ray diffraction analysis. The cytotoxicity study, performedon human leukemia cells MOLT-4 and HL-60, demonstrates that the activity of the vanadocene complexes strongly depends on the nature of the coordinated chelating ligand. The high cytotoxicity was observed for the complex bearing 2,2'-bipyridine, [(?5-C5H4Me)2V(bpy)][OTf]2, that shows IC50 values close to the data observed for cisplatin.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganica Chimica Acta

ISSN

0020-1693

e-ISSN

—

Svazek periodika

427

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

211-218

Kód UT WoS článku

000349462500029

EID výsledku v databázi Scopus

2-s2.0-84921350925