Can Substitution of Chlorides Enhance the Cytotoxicity of Vanadocene Dichloride?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896348" target="_blank" >RIV/00216275:25310/13:39896348 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/13:10138938

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/ejic.201201505/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ejic.201201505/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejic.201201505" target="_blank" >10.1002/ejic.201201505</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can Substitution of Chlorides Enhance the Cytotoxicity of Vanadocene Dichloride?

Popis výsledku v původním jazyce

A series of vanadocene complexes [Cp2V(L)][OTf]2 (Cp = 5-C5H5, 5-C5H4Me; L = phen, 5-NO2-phen, 5-NH2-phen, 4,7-Ph2-phen) was prepared and characterized by mass spectrometry and EPR spectroscopy. Structures of two complexes that contain an N,N-chelating ligand, [(5-C5H4Me)2V(phen)][OTf]2.0.5Me2CO and [(5-C5H5)2V(5-NH2-phen)][OTf]2, and the triflate intermediate [(5-C5H5)2V(OTf)2] were further confirmed by X-ray diffraction analysis. The cytotoxicity study has shown that complexes that contain phenanthroline ligands have considerably higher in vitro activity toward human leukemia cells MOLT-4 and HL-60 than their parent dichlorides ([Cp2VCl2]). The high activity of these complexes coheres with their higher stability in various aqueous media. This study has further shown that substitution of chloride ligands in the vanadocene dichloride has a considerably higher effect on cytotoxicity than expected on the basis of established mechanistic rules.

Název v anglickém jazyce

Can Substitution of Chlorides Enhance the Cytotoxicity of Vanadocene Dichloride?

Popis výsledku anglicky

A series of vanadocene complexes [Cp2V(L)][OTf]2 (Cp = 5-C5H5, 5-C5H4Me; L = phen, 5-NO2-phen, 5-NH2-phen, 4,7-Ph2-phen) was prepared and characterized by mass spectrometry and EPR spectroscopy. Structures of two complexes that contain an N,N-chelating ligand, [(5-C5H4Me)2V(phen)][OTf]2.0.5Me2CO and [(5-C5H5)2V(5-NH2-phen)][OTf]2, and the triflate intermediate [(5-C5H5)2V(OTf)2] were further confirmed by X-ray diffraction analysis. The cytotoxicity study has shown that complexes that contain phenanthroline ligands have considerably higher in vitro activity toward human leukemia cells MOLT-4 and HL-60 than their parent dichlorides ([Cp2VCl2]). The high activity of these complexes coheres with their higher stability in various aqueous media. This study has further shown that substitution of chloride ligands in the vanadocene dichloride has a considerably higher effect on cytotoxicity than expected on the basis of established mechanistic rules.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Inorganic Chemistry

ISSN

1434-1948

e-ISSN

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Svazek periodika

2013

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

2665-2672

Kód UT WoS článku

000318510300022

EID výsledku v databázi Scopus

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