Tetrafluoro-4-pyridyl substituted cyclopentadienyl molybdenum(II) compounds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10283566" target="_blank" >RIV/00216208:11150/14:10283566 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216275:25310/14:39896485

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jorganchem.2013.10.034" target="_blank" >http://dx.doi.org/10.1016/j.jorganchem.2013.10.034</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jorganchem.2013.10.034" target="_blank" >10.1016/j.jorganchem.2013.10.034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tetrafluoro-4-pyridyl substituted cyclopentadienyl molybdenum(II) compounds

Popis výsledku v původním jazyce

The allyl molybdenum(II) complex bearing tetrafluoro-4-pyridyl substituted cyclopentadienyl ligand, [(?3-C3H5){?5-C5H3(C5F4N)}Mo(CO)2], was synthesized and characterized by analytical and spectroscopic methods. This compound was found to be suitable precursor for complexes of the type [{?5-C5H4(C5F4N)}Mo(CO)2(NNL)][BF4] where NNL is N,N-chelating ligand. The biological study has shown that these complexes are cytotoxic active toward human leukemia cells MOLT-4. The cytotoxicity strongly depends on nature of the coordinated N,N-chelating ligand. The compounds bearing 1,10-phenanthroline (phen) and 2,2'-biquinoline (bq) are only medium active while the complexes with 4,7-diphenyl-1,10-phenanthroline (4,7-Ph2-phen) and 5-amino-1,10-phenanthroline (5-NH2-phen) show considerably higher activity than cisplatin. This study further describe the X-ray structures of [(?3-C3H5){?5-C5H4(C5F4N)}Mo(CO)2], [(?3-C3H5){?5-C5H3(1,3-C5F4N)2}Mo(CO)2], [{?5-C5H4(C5F4N)}Mo(CO)2(phen)][BF4] and [{?5-C5H4(C5F

Název v anglickém jazyce

Tetrafluoro-4-pyridyl substituted cyclopentadienyl molybdenum(II) compounds

Popis výsledku anglicky

The allyl molybdenum(II) complex bearing tetrafluoro-4-pyridyl substituted cyclopentadienyl ligand, [(?3-C3H5){?5-C5H3(C5F4N)}Mo(CO)2], was synthesized and characterized by analytical and spectroscopic methods. This compound was found to be suitable precursor for complexes of the type [{?5-C5H4(C5F4N)}Mo(CO)2(NNL)][BF4] where NNL is N,N-chelating ligand. The biological study has shown that these complexes are cytotoxic active toward human leukemia cells MOLT-4. The cytotoxicity strongly depends on nature of the coordinated N,N-chelating ligand. The compounds bearing 1,10-phenanthroline (phen) and 2,2'-biquinoline (bq) are only medium active while the complexes with 4,7-diphenyl-1,10-phenanthroline (4,7-Ph2-phen) and 5-amino-1,10-phenanthroline (5-NH2-phen) show considerably higher activity than cisplatin. This study further describe the X-ray structures of [(?3-C3H5){?5-C5H4(C5F4N)}Mo(CO)2], [(?3-C3H5){?5-C5H3(1,3-C5F4N)2}Mo(CO)2], [{?5-C5H4(C5F4N)}Mo(CO)2(phen)][BF4] and [{?5-C5H4(C5F

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Organometallic Chemistry

ISSN

0022-328X

e-ISSN

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Svazek periodika

749

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

387-393

Kód UT WoS článku

000327939000056

EID výsledku v databázi Scopus

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