Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F23%3A39920461" target="_blank" >RIV/00216275:25310/23:39920461 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11150/23:10468149
Výsledek na webu
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cplu.202300374" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cplu.202300374</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cplu.202300374" target="_blank" >10.1002/cplu.202300374</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies
Popis výsledku v původním jazyce
A series of molybdenum(II) compounds [(& eta;5-Cp')Mo(CO)2(L2)][BF4] (Cp'=C5H4(CH2)2SPh, C9H6(CH2)2OMe, L2=N,N-chelating ligand) have been synthesized and characterized by spectroscopic and analytical methods including X-ray crystallography. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution in the & pi;-ligand in combination with suitable N,N-chelating ligand can lead to species with cytotoxicity considerably higher than reported to cisplatin. Unusually high activity was observed for compounds bearing phenanthroline ligands [{& eta;5-C9H6(CH2)2OMe}Mo(CO)2(3,4,7,8-Me4phen)][BF4] (IC50=0.7 & PLUSMN;0.3 & mu;M) and [{& eta;5-C9H6(CH2)2OMe}Mo(CO)2(4,7-Ph2phen)][BF4] (IC50 values 0.8 & PLUSMN;0.4 & mu;M). A series of cyclopentadienyl and indenyl molybdenum(II) compounds bearing N,N-chelating ligands has been synthesized and characterized by analytical methods including X-ray crystallography. Considerably enhanced cytotoxicity toward T-lymphocytic leukemia cells MOLT-4 was observed for derivatives bearing ether and thioether ligands. Species bearing phenanthroline ligands 3,4,7,8-Me4phen and 4,7-Ph2phen exhibit activity more than 20 times stronger than cisplatin.
Název v anglickém jazyce
Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies
Popis výsledku anglicky
A series of molybdenum(II) compounds [(& eta;5-Cp')Mo(CO)2(L2)][BF4] (Cp'=C5H4(CH2)2SPh, C9H6(CH2)2OMe, L2=N,N-chelating ligand) have been synthesized and characterized by spectroscopic and analytical methods including X-ray crystallography. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution in the & pi;-ligand in combination with suitable N,N-chelating ligand can lead to species with cytotoxicity considerably higher than reported to cisplatin. Unusually high activity was observed for compounds bearing phenanthroline ligands [{& eta;5-C9H6(CH2)2OMe}Mo(CO)2(3,4,7,8-Me4phen)][BF4] (IC50=0.7 & PLUSMN;0.3 & mu;M) and [{& eta;5-C9H6(CH2)2OMe}Mo(CO)2(4,7-Ph2phen)][BF4] (IC50 values 0.8 & PLUSMN;0.4 & mu;M). A series of cyclopentadienyl and indenyl molybdenum(II) compounds bearing N,N-chelating ligands has been synthesized and characterized by analytical methods including X-ray crystallography. Considerably enhanced cytotoxicity toward T-lymphocytic leukemia cells MOLT-4 was observed for derivatives bearing ether and thioether ligands. Species bearing phenanthroline ligands 3,4,7,8-Me4phen and 4,7-Ph2phen exhibit activity more than 20 times stronger than cisplatin.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
ChemPlusChem
ISSN
2192-6506
e-ISSN
2192-6506
Svazek periodika
88
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
11
Strana od-do
"e202300374"
Kód UT WoS článku
001060062200001
EID výsledku v databázi Scopus
2-s2.0-85169838859