Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901700" target="_blank" >RIV/00216275:25310/16:39901700 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/16:10322420

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ejic.201501133" target="_blank" >http://dx.doi.org/10.1002/ejic.201501133</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ejic.201501133" target="_blank" >10.1002/ejic.201501133</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents

Popis výsledku v původním jazyce

A series of the cyclopentadienyl and indenyl molybdenum compounds bearing alkylammonium functions [(eta(5)-Cp')Mo(CO)(2)(L-N,L-N)][BF4](2) were synthesized and characterized by analytical and spectroscopic methods. The structures of [{eta(5)-C5H4CH2CH2NH(CH2)(5)}Mo(CO)(2)(4,7-Ph-2-phen)][BF4](2) (4,7-Ph-2-phen = 4,7-dipheny1-1,10-phenanthroline) and [(eta(5)-C9H6CH2CH2NHMe2)Mo(CO)(2)(phen)][BF4](2) (phen = 1,10-phenanthroline) were determined by X-ray crystallography. All of the synthesized compounds exhibit high activity against the human leukemia cell lines MOLT-4 and HL-60. They are approximately one order of magnitude more active than cisplatin. This study has proven that the modification of the outer coordination sphere of molybdenum complexes has a strong impact on their activity and may be successfully used for the design of new highly cytotoxic active species.

Název v anglickém jazyce

Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents

Popis výsledku anglicky

A series of the cyclopentadienyl and indenyl molybdenum compounds bearing alkylammonium functions [(eta(5)-Cp')Mo(CO)(2)(L-N,L-N)][BF4](2) were synthesized and characterized by analytical and spectroscopic methods. The structures of [{eta(5)-C5H4CH2CH2NH(CH2)(5)}Mo(CO)(2)(4,7-Ph-2-phen)][BF4](2) (4,7-Ph-2-phen = 4,7-dipheny1-1,10-phenanthroline) and [(eta(5)-C9H6CH2CH2NHMe2)Mo(CO)(2)(phen)][BF4](2) (phen = 1,10-phenanthroline) were determined by X-ray crystallography. All of the synthesized compounds exhibit high activity against the human leukemia cell lines MOLT-4 and HL-60. They are approximately one order of magnitude more active than cisplatin. This study has proven that the modification of the outer coordination sphere of molybdenum complexes has a strong impact on their activity and may be successfully used for the design of new highly cytotoxic active species.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Inorganic Chemistry

ISSN

1434-1948

e-ISSN

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Svazek periodika

Neuveden

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

519-529

Kód UT WoS článku

000370352400009

EID výsledku v databázi Scopus

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