Omentin-1 plasma levels and cholesterol metabolism in obese patients with diabetes mellitus typ 1: impact of weight reduction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10314096" target="_blank" >RIV/00216208:11150/15:10314096 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10314096

Výsledek na webu

<a href="http://www.nature.com/nutd/journal/v5/n11/full/nutd201533a.html" target="_blank" >http://www.nature.com/nutd/journal/v5/n11/full/nutd201533a.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nutd.2015.33" target="_blank" >10.1038/nutd.2015.33</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Omentin-1 plasma levels and cholesterol metabolism in obese patients with diabetes mellitus typ 1: impact of weight reduction

Popis výsledku v původním jazyce

Background: Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. Plasma levels of omentin-1 are decreased in obesity and other insulin-resistant states. Insulin resistence contributes to the changes of cholesterol synthesis and absorption as well. The aim of this study was to characterise omentin-1 plasma levels in obese patients with diabetes melltius type 1 during weight reduction, and to elucidate the relationship between cholesterol metabolism and omentin-1. Methods: Plasma levels of omentin-1 were measured in obese type 1 diabetics (n=14, body mass index )30 kg m-2, age 29-62 years) by enzyme-linked immunosorbent assay (BioVendor). Gas chromatography with flame ionisation detector (Fisons Plc.,) was usedto measure squalene and non-cholesterol sterols - markers of cholesterol synthesis and absorption (phase I). Measurements were repeated after 1 month (phase II; 1 week of fasting in the hospital setting and 3 weeks on a diet containing 15

Název v anglickém jazyce

Omentin-1 plasma levels and cholesterol metabolism in obese patients with diabetes mellitus typ 1: impact of weight reduction

Popis výsledku anglicky

Background: Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. Plasma levels of omentin-1 are decreased in obesity and other insulin-resistant states. Insulin resistence contributes to the changes of cholesterol synthesis and absorption as well. The aim of this study was to characterise omentin-1 plasma levels in obese patients with diabetes melltius type 1 during weight reduction, and to elucidate the relationship between cholesterol metabolism and omentin-1. Methods: Plasma levels of omentin-1 were measured in obese type 1 diabetics (n=14, body mass index )30 kg m-2, age 29-62 years) by enzyme-linked immunosorbent assay (BioVendor). Gas chromatography with flame ionisation detector (Fisons Plc.,) was usedto measure squalene and non-cholesterol sterols - markers of cholesterol synthesis and absorption (phase I). Measurements were repeated after 1 month (phase II; 1 week of fasting in the hospital setting and 3 weeks on a diet containing 15

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition and Diabetes [online]

ISSN

2044-4052

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

000368900100001

EID výsledku v databázi Scopus

2-s2.0-84946563175