Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10368164" target="_blank" >RIV/00216208:11150/17:10368164 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11160/17:10368164 RIV/00179906:_____/17:10368164 RIV/61989592:15110/17:73583797 RIV/61989592:15310/17:73583797
Výsledek na webu
<a href="http://www.degruyter.com/view/j/pteridines.2017.28.issue-3-4/pterid-2017-0005/pterid-2017-0005.xml" target="_blank" >http://www.degruyter.com/view/j/pteridines.2017.28.issue-3-4/pterid-2017-0005/pterid-2017-0005.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/pterid-2017-0005" target="_blank" >10.1515/pterid-2017-0005</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients
Popis výsledku v původním jazyce
In the present study, we determined complex indices of inflammatory activity and compared the performance of these indices as prognostic biomarkers in a cohort of breast cancer patients. All proposed composite biomarkers could be evaluated in 418 out of 474 patients in the cohort with complete data on peripheral blood cell count, urinary neopterin, albumin and C-reactive protein. Neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, systemic inflammatory index, Glasgow prognostic index, modified Glasgow prognostic index, prognostic nutritional index and C-reactive protein/albumin ratio were calculated and further complex indices were proposed. Although a number of the investigated indices were significantly associated with survival in the univariate analysis, only age and stage, but none of the laboratory biomarkers or composite biomarkers, were significant predictors of survival in the whole group in the multivariate analysis. In patients evaluated before the start of the treatment, age, stage and urinary neopterin were significant predictors of survival. These results underscore the importance of neopterin as a prognostic biomarker in breast cancer.
Název v anglickém jazyce
Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients
Popis výsledku anglicky
In the present study, we determined complex indices of inflammatory activity and compared the performance of these indices as prognostic biomarkers in a cohort of breast cancer patients. All proposed composite biomarkers could be evaluated in 418 out of 474 patients in the cohort with complete data on peripheral blood cell count, urinary neopterin, albumin and C-reactive protein. Neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, systemic inflammatory index, Glasgow prognostic index, modified Glasgow prognostic index, prognostic nutritional index and C-reactive protein/albumin ratio were calculated and further complex indices were proposed. Although a number of the investigated indices were significantly associated with survival in the univariate analysis, only age and stage, but none of the laboratory biomarkers or composite biomarkers, were significant predictors of survival in the whole group in the multivariate analysis. In patients evaluated before the start of the treatment, age, stage and urinary neopterin were significant predictors of survival. These results underscore the importance of neopterin as a prognostic biomarker in breast cancer.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/NV16-32030A" target="_blank" >NV16-32030A: Využití disulfiramu v nové roli léčebného prostředku pro rekurentní metastatické nádory prsu rezistentní na chemo a endokrinní terapii</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Pteridines
ISSN
0933-4807
e-ISSN
—
Svazek periodika
28
Číslo periodika v rámci svazku
3-4
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
8
Strana od-do
213-220
Kód UT WoS článku
000416827700012
EID výsledku v databázi Scopus
2-s2.0-85038004175