Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10370420" target="_blank" >RIV/00216208:11150/17:10370420 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/17:10370420

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jflm.2017.07.002" target="_blank" >http://dx.doi.org/10.1016/j.jflm.2017.07.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jflm.2017.07.002" target="_blank" >10.1016/j.jflm.2017.07.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia

Popis výsledku v původním jazyce

Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells. In the study herein described, endocan concentrations were determined in postmortem serum, urine and vitreous humor samples collected during autopsy in a series of cases that underwent medicolegal investigations. A total of 76 autopsy cases were selected and three study groups (hypothermia group, sepsis group and non-hypothermia/non-sepsis group) prospectively formed during the study period. The obtained results seem to indicate that exposure to cold and subsequent death is not distinguished by significant endothelial dysfunction causing enhanced endocan secretion. (C) 2017 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Název v anglickém jazyce

Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia

Popis výsledku anglicky

Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells. In the study herein described, endocan concentrations were determined in postmortem serum, urine and vitreous humor samples collected during autopsy in a series of cases that underwent medicolegal investigations. A total of 76 autopsy cases were selected and three study groups (hypothermia group, sepsis group and non-hypothermia/non-sepsis group) prospectively formed during the study period. The obtained results seem to indicate that exposure to cold and subsequent death is not distinguished by significant endothelial dysfunction causing enhanced endocan secretion. (C) 2017 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30501 - Forensic science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Forensic and Legal Medicine

ISSN

1752-928X

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

39-43

Kód UT WoS článku

000407721900007

EID výsledku v databázi Scopus

2-s2.0-85022051051