S100A4 Protein in Inflammatory Bowel Disease: Results of a Single Centre Prospective Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10375153" target="_blank" >RIV/00216208:11150/17:10375153 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/17:10375153

Výsledek na webu

<a href="https://actamedica.lfhk.cuni.cz/60/3/0108/" target="_blank" >https://actamedica.lfhk.cuni.cz/60/3/0108/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/18059694.2018.2" target="_blank" >10.14712/18059694.2018.2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

S100A4 Protein in Inflammatory Bowel Disease: Results of a Single Centre Prospective Study

Popis výsledku v původním jazyce

Introduction: The aim of our study was to assess association of serum S100A4 protein with ulcerative colitis (UC) and Crohn&apos;s disease (CD). Methods: Study included 118 subjects: 93 patients with CD, 16 with UC and 9 controls. In CD group, 20/93 patients had B1 phenotype, 19/93 B2, 20/93 B3 and 34/93 B2 + B3. L1 involvement was present in 15/93, L2 in 14/93 and L3 in 64/93 patients. Serum S100A4 concentration was investigated in peripheral venous blood samples by means of ELISA. Results: Serum S100A4 was significantly higher in UC (158.6 +- 56.2 ng/mL), p = 0.019 and in CD (154.4 +- 52.1 ng/mL), p = 0.007 compared to controls (104.8 +- 40.5 ng/mL). No difference in S100A4 was revealed between UC and CD, p &gt; 0.05. Serum S100A4 in each CD subgroup (according to behaviour) was significantly higher compared to controls, p &lt; 0.05. Serum S100A4 was significantly higher in L2 (144.6 +- 44.2 ng/mL), p = 0.041 and in L3 (163.0 +- 52.8 ng/mL), p = 0.002 compared to controls and in L3 compared to L1 (126.9 +- 47.6 ng/mL), p = 0.017. Conclusion: Association of serum S100A4 protein with UC and CD was confirmed. In CD, disease behaviour did not influence serum concentration of S100A4 protein. In CD, higher levels of serum S100A4 were observed in patients with ileo-colonic and colonic involvement compared to those with isolated small bowel involvement.

Název v anglickém jazyce

S100A4 Protein in Inflammatory Bowel Disease: Results of a Single Centre Prospective Study

Popis výsledku anglicky

Introduction: The aim of our study was to assess association of serum S100A4 protein with ulcerative colitis (UC) and Crohn&apos;s disease (CD). Methods: Study included 118 subjects: 93 patients with CD, 16 with UC and 9 controls. In CD group, 20/93 patients had B1 phenotype, 19/93 B2, 20/93 B3 and 34/93 B2 + B3. L1 involvement was present in 15/93, L2 in 14/93 and L3 in 64/93 patients. Serum S100A4 concentration was investigated in peripheral venous blood samples by means of ELISA. Results: Serum S100A4 was significantly higher in UC (158.6 +- 56.2 ng/mL), p = 0.019 and in CD (154.4 +- 52.1 ng/mL), p = 0.007 compared to controls (104.8 +- 40.5 ng/mL). No difference in S100A4 was revealed between UC and CD, p &gt; 0.05. Serum S100A4 in each CD subgroup (according to behaviour) was significantly higher compared to controls, p &lt; 0.05. Serum S100A4 was significantly higher in L2 (144.6 +- 44.2 ng/mL), p = 0.041 and in L3 (163.0 +- 52.8 ng/mL), p = 0.002 compared to controls and in L3 compared to L1 (126.9 +- 47.6 ng/mL), p = 0.017. Conclusion: Association of serum S100A4 protein with UC and CD was confirmed. In CD, disease behaviour did not influence serum concentration of S100A4 protein. In CD, higher levels of serum S100A4 were observed in patients with ileo-colonic and colonic involvement compared to those with isolated small bowel involvement.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Medica (Hradec Králové)

ISSN

1211-4286

e-ISSN

—

Svazek periodika

60

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

108-113

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85046283311