Hepcidin in newly diagnosed inflammatory bowel disease in children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73590124" target="_blank" >RIV/61989592:15110/18:73590124 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/18:N0000079

Výsledek na webu

<a href="http://dx.doi.org/10.1111/jpc.14093" target="_blank" >http://dx.doi.org/10.1111/jpc.14093</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jpc.14093" target="_blank" >10.1111/jpc.14093</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hepcidin in newly diagnosed inflammatory bowel disease in children

Popis výsledku v původním jazyce

Aim: Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn&apos;s disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. Methods: Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross-sectional study. We analysed levels of serum hepcidin, C-reactive protein, iron, ferritin, soluble transferrin receptors, blood count and faecal calprotectin in all subjects. Serum hepcidin levels were measured by reverse-phase liquid chromatography. The Paediatric Crohn&apos;s Disease Activity Index was used to evaluate CD in children, and Paediatric Ulcerative Colitis Activity Index was used for the assessment of UC disease activity. Results: Subjects with CD (n = 53) had significantly higher serum hepcidin levels compared with subjects with UC (n = 23) – 22.6 ng/mL (range 8.5–65.0) versus 6.5 ng/mL (range 2.4–25.8) (P &lt; 0.05). Hepcidin was independently associated with ferritin levels in all IBD patients (P &lt; 0.05). Moreover, there was a significant positive correlation between hepcidin and platelet count (P &lt; 0.05) in children with CD and a negative correlation between hepcidin and faecal calprotectin (P &lt; 0.05) in children with UC. Conclusion: Different hepcidin levels between children with newly diagnosed CD and UC suggest the distinct contribution of iron deficiency and/or systemic inflammation to anaemia and may help clinicians choose the best anti-anaemic treatment. © 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians)

Název v anglickém jazyce

Hepcidin in newly diagnosed inflammatory bowel disease in children

Popis výsledku anglicky

Aim: Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn&apos;s disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. Methods: Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross-sectional study. We analysed levels of serum hepcidin, C-reactive protein, iron, ferritin, soluble transferrin receptors, blood count and faecal calprotectin in all subjects. Serum hepcidin levels were measured by reverse-phase liquid chromatography. The Paediatric Crohn&apos;s Disease Activity Index was used to evaluate CD in children, and Paediatric Ulcerative Colitis Activity Index was used for the assessment of UC disease activity. Results: Subjects with CD (n = 53) had significantly higher serum hepcidin levels compared with subjects with UC (n = 23) – 22.6 ng/mL (range 8.5–65.0) versus 6.5 ng/mL (range 2.4–25.8) (P &lt; 0.05). Hepcidin was independently associated with ferritin levels in all IBD patients (P &lt; 0.05). Moreover, there was a significant positive correlation between hepcidin and platelet count (P &lt; 0.05) in children with CD and a negative correlation between hepcidin and faecal calprotectin (P &lt; 0.05) in children with UC. Conclusion: Different hepcidin levels between children with newly diagnosed CD and UC suggest the distinct contribution of iron deficiency and/or systemic inflammation to anaemia and may help clinicians choose the best anti-anaemic treatment. © 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians)

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

<a href="/cs/project/GA15-13732S" target="_blank" >GA15-13732S: Molekulární podstata erytroidního defektu a narušené utilizace železa u deficitu DMT1 a u Diamondovy-Blackfanovy anémie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF PAEDIATRICS AND CHILD HEALTH

ISSN

1034-4810

e-ISSN

—

Svazek periodika

54

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

AU - Austrálie

Počet stran výsledku

6

Strana od-do

1362-1367

Kód UT WoS článku

000453386100014

EID výsledku v databázi Scopus

2-s2.0-85057628254