Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10380714" target="_blank" >RIV/00216208:11150/18:10380714 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/18:10380714 RIV/00216208:11320/18:10380714 RIV/00179906:_____/18:10380714

Výsledek na webu

<a href="http://www.futuremedicine.com/doi/full/10.2217/pgs-2016-0182" target="_blank" >http://www.futuremedicine.com/doi/full/10.2217/pgs-2016-0182</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/pgs-2016-0182" target="_blank" >10.2217/pgs-2016-0182</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways?

Popis výsledku v původním jazyce

This study found the association of MTX non-response with SNPs in MTHFR (rs1801131, rs1801133), MS (rs1805087), MTRR (rs1801394) and ATIC (rs2372536, rs4673993, rs7563206, rs12995526). Three haplotypes in GGH (CC haplotype for rs3758149 and rs12681874) and ATIC (haplotypes CGTTT and CTTTC for ATIC combination 1 and 2) genes were found to be associated with nonresponse to MTX. Importantly, these haplotypes have high haplotype frequencies (22.4%, 48.1%, 34.6%, respectively). Therefore, we can hypothesize that the influence of SNPs in the de novo purine synthesis pathway, polyglutamation pathway and in ADORA2A receptor is mutually strengthened, i.e. it leads to phenotypic manifestation with higher clinical significance observed as non-response to MTX treatment.

Název v anglickém jazyce

Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways?

Popis výsledku anglicky

This study found the association of MTX non-response with SNPs in MTHFR (rs1801131, rs1801133), MS (rs1805087), MTRR (rs1801394) and ATIC (rs2372536, rs4673993, rs7563206, rs12995526). Three haplotypes in GGH (CC haplotype for rs3758149 and rs12681874) and ATIC (haplotypes CGTTT and CTTTC for ATIC combination 1 and 2) genes were found to be associated with nonresponse to MTX. Importantly, these haplotypes have high haplotype frequencies (22.4%, 48.1%, 34.6%, respectively). Therefore, we can hypothesize that the influence of SNPs in the de novo purine synthesis pathway, polyglutamation pathway and in ADORA2A receptor is mutually strengthened, i.e. it leads to phenotypic manifestation with higher clinical significance observed as non-response to MTX treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmacogenomics

ISSN

1462-2416

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

379-381

Kód UT WoS článku

000431864400002

EID výsledku v databázi Scopus

2-s2.0-85045384991