Calcific aortic valve stenosis - comparison of inflammatory lesions in the left, right, and non-coronary cusp

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10434265" target="_blank" >RIV/00216208:11150/21:10434265 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/21:10434265

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=u.hCPH0jfB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=u.hCPH0jfB</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.prp.2021.153636" target="_blank" >10.1016/j.prp.2021.153636</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Calcific aortic valve stenosis - comparison of inflammatory lesions in the left, right, and non-coronary cusp

Popis výsledku v původním jazyce

Background: Calcific aortic valve stenosis (CAVS) is the most frequent acquired heart valve disease in the developed world and the most common cause of heart valve replacement, particularly in older adults. It is considered a form of atherosclerosis and, like the latter, of inflammatory pathogenesis. Methods: The incidence and severity of features of chronic inflammation (vascularization, cellular infiltration, bone metaplasia, calcification) in surgically resected semilunar cusps of a tricuspid aortic valve in 100 patients with CAVS were assessed. A novel method of placing metal clips during the operation by the surgeon to distinguish individual cusps was implemented, allowing the pathologist to associate lesions to particular cusps. The findings were evaluated statistically. Results: The median age of the cohort was 73 years. There was a male predominance of 3.5:1. Almost all the patients had a medical history of risk factors - hypertension (92x), diabetes (51x), and dyslipidaemia (85x). Statistical evaluation of the pathological findings showed that the left cusp was least affected by calcification, vascularization, and chronic inflammation, compared to both the right and non-coronary cusps. On the other hand, the left cusp was the most common site of bone metaplasia. The reason for these differences is unknown. We speculate about mechanobiological effects of abnormal hemodynamics. Conclusions: Chronic inflammation plays a significant role in pathogenesis of CAVS. Distinguishing the resected aortic valve cusps by placing metal clips is a useful method to study potential differences (topography) in the pathology of individual cusps.

Název v anglickém jazyce

Calcific aortic valve stenosis - comparison of inflammatory lesions in the left, right, and non-coronary cusp

Popis výsledku anglicky

Background: Calcific aortic valve stenosis (CAVS) is the most frequent acquired heart valve disease in the developed world and the most common cause of heart valve replacement, particularly in older adults. It is considered a form of atherosclerosis and, like the latter, of inflammatory pathogenesis. Methods: The incidence and severity of features of chronic inflammation (vascularization, cellular infiltration, bone metaplasia, calcification) in surgically resected semilunar cusps of a tricuspid aortic valve in 100 patients with CAVS were assessed. A novel method of placing metal clips during the operation by the surgeon to distinguish individual cusps was implemented, allowing the pathologist to associate lesions to particular cusps. The findings were evaluated statistically. Results: The median age of the cohort was 73 years. There was a male predominance of 3.5:1. Almost all the patients had a medical history of risk factors - hypertension (92x), diabetes (51x), and dyslipidaemia (85x). Statistical evaluation of the pathological findings showed that the left cusp was least affected by calcification, vascularization, and chronic inflammation, compared to both the right and non-coronary cusps. On the other hand, the left cusp was the most common site of bone metaplasia. The reason for these differences is unknown. We speculate about mechanobiological effects of abnormal hemodynamics. Conclusions: Chronic inflammation plays a significant role in pathogenesis of CAVS. Distinguishing the resected aortic valve cusps by placing metal clips is a useful method to study potential differences (topography) in the pathology of individual cusps.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

<a href="/cs/project/LM2018125" target="_blank" >LM2018125: Banka klinických vzorků</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pathology: Research and Practice

ISSN

0344-0338

e-ISSN

1618-0631

Svazek periodika

227

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

153636

Kód UT WoS článku

000704990700005

EID výsledku v databázi Scopus

2-s2.0-85116070083