Pregnancy in homozygous familial hypercholesterolemia-A case series

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F22%3A10454374" target="_blank" >RIV/00216208:11150/22:10454374 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/22:10454374

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3EU~.6xvtJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3EU~.6xvtJ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1744-9987.13841" target="_blank" >10.1111/1744-9987.13841</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pregnancy in homozygous familial hypercholesterolemia-A case series

Popis výsledku v původním jazyce

IntroductionFamilial hypercholesterolemia (FH) is an autosomal codominant lipid metabolism disorder. It results in lifelong elevation of plasmatic low-density lipoprotein cholesterol (LDL-C) levels, followed by premature atherosclerosis. In women, pregnancy and lactation represent an additional risk due to association of physiological changes, pre-existing dyslipidemia, and limited therapeutic possibilities and experiences. Methods of extracorporeal LDL-apheresis represent a suitable therapeutic approach. Case seriesWe present our experience in case reports of six HoFH women and their 13 pregnancies (nine successful, three abortions, and one interruption). One patient experienced a lethal complication of her pregnancy. Of the nine successful pregnancies, two cases were treated by LDL-apheresis. ConclusionPregnancy in HoFH women represents substantial risk; however, patients without signs of decompensated cardiovascular disease can have a good prognosis. LDL-apheresis plays an important role in the management of pregnancy in HoFH.

Název v anglickém jazyce

Pregnancy in homozygous familial hypercholesterolemia-A case series

Popis výsledku anglicky

IntroductionFamilial hypercholesterolemia (FH) is an autosomal codominant lipid metabolism disorder. It results in lifelong elevation of plasmatic low-density lipoprotein cholesterol (LDL-C) levels, followed by premature atherosclerosis. In women, pregnancy and lactation represent an additional risk due to association of physiological changes, pre-existing dyslipidemia, and limited therapeutic possibilities and experiences. Methods of extracorporeal LDL-apheresis represent a suitable therapeutic approach. Case seriesWe present our experience in case reports of six HoFH women and their 13 pregnancies (nine successful, three abortions, and one interruption). One patient experienced a lethal complication of her pregnancy. Of the nine successful pregnancies, two cases were treated by LDL-apheresis. ConclusionPregnancy in HoFH women represents substantial risk; however, patients without signs of decompensated cardiovascular disease can have a good prognosis. LDL-apheresis plays an important role in the management of pregnancy in HoFH.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

<a href="/cs/project/NV17-28882A" target="_blank" >NV17-28882A: Genetické polymorfismy, MiRNA a vybrané bioindikátory aktivity - vzájemné vztahy při diagnostice a léčbě těžké familiární hypercholesterolemie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Therapeutic Apheresis and Dialysis

ISSN

1744-9979

e-ISSN

1744-9987

Svazek periodika

26

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

8

Strana od-do

89-96

Kód UT WoS článku

000896663600001

EID výsledku v databázi Scopus

2-s2.0-85143893405