Photosynthesis-inhibiting effects of 2-benzylsulphanylbenzimidazoles in spinach chloroplasts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124174" target="_blank" >RIV/00216208:11160/12:10124174 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/content/pdf/10.2478%2Fs11696-012-0192-9" target="_blank" >http://link.springer.com/content/pdf/10.2478%2Fs11696-012-0192-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11696-012-0192-9" target="_blank" >10.2478/s11696-012-0192-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Photosynthesis-inhibiting effects of 2-benzylsulphanylbenzimidazoles in spinach chloroplasts

Popis výsledku v původním jazyce

Inhibition of photosynthetic electron transport (PET) in spinach chloroplasts by nineteen 2-benzylsulphanylbenzimidazoles (BZA) was studied. BZA were found to inhibit photosynthetic electron transport (PET) and for their inhibitory efficiency, electronicproperties of the R substituent on the benzyl moiety are decisive. The PET inhibiting activity of the studied BZA expressed as IC50 varied in the range from 28.5 mu M (R = 3,5-(CF3)(2)) to 394.5 mu M (R = 2,4-(NO2)(2)). For compounds with R = H, 4-CH3,3-CH3, 3-OCH3, 4-F, 3-F, 4-Cl, 3-Cl, 2-Cl, 4-Br, 3-Br, 3,4-F-2, 3,4-Cl-2, 3-CF3, 3,5-(CF3)(2) linear increase of the inhibitory activity with the increasing value of the substituent's sigma constant up to 0.86 was observed. Further increase of the sigmaconstant resulted in a sharp activity decrease of the corresponding compounds (R = 2-F-6-Cl, 2-NO2, 3,5-(NO2)(2), 2,4-(NO2)(2)). Using EPR spectroscopy and an artificial electron donor diphenyl carbazide it was found that the site of BZA

Název v anglickém jazyce

Photosynthesis-inhibiting effects of 2-benzylsulphanylbenzimidazoles in spinach chloroplasts

Popis výsledku anglicky

Inhibition of photosynthetic electron transport (PET) in spinach chloroplasts by nineteen 2-benzylsulphanylbenzimidazoles (BZA) was studied. BZA were found to inhibit photosynthetic electron transport (PET) and for their inhibitory efficiency, electronicproperties of the R substituent on the benzyl moiety are decisive. The PET inhibiting activity of the studied BZA expressed as IC50 varied in the range from 28.5 mu M (R = 3,5-(CF3)(2)) to 394.5 mu M (R = 2,4-(NO2)(2)). For compounds with R = H, 4-CH3,3-CH3, 3-OCH3, 4-F, 3-F, 4-Cl, 3-Cl, 2-Cl, 4-Br, 3-Br, 3,4-F-2, 3,4-Cl-2, 3-CF3, 3,5-(CF3)(2) linear increase of the inhibitory activity with the increasing value of the substituent's sigma constant up to 0.86 was observed. Further increase of the sigmaconstant resulted in a sharp activity decrease of the corresponding compounds (R = 2-F-6-Cl, 2-NO2, 3,5-(NO2)(2), 2,4-(NO2)(2)). Using EPR spectroscopy and an artificial electron donor diphenyl carbazide it was found that the site of BZA

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

0366-6352

e-ISSN

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Svazek periodika

66

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

795-799

Kód UT WoS článku

000305460300011

EID výsledku v databázi Scopus

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