The Retention Behavior of Acidic, Basic and Neutral Pharmaceuticals on the Deactivated Polybutadiene Zirconia Phase
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124976" target="_blank" >RIV/00216208:11160/12:10124976 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.ingentaconnect.com/content/ben/cac/2012/00000008/00000004/art00018" target="_blank" >http://www.ingentaconnect.com/content/ben/cac/2012/00000008/00000004/art00018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/157341112803216726" target="_blank" >10.2174/157341112803216726</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Retention Behavior of Acidic, Basic and Neutral Pharmaceuticals on the Deactivated Polybutadiene Zirconia Phase
Popis výsledku v původním jazyce
Reversed zirconia-based stationary phases belong among interesting alternatives of widely used RP silica phases. Zirconia displays specific surface properties, which are responsible for a unique retention mechanism. Furthermore, especially for acidic analytes it is necessary to add a strong Lewis base to the mobile phase mainly to improve the separation efficiency. However, commonly recommended strong Lewis base buffers are not volatile and therefore are incompatible with a mass spectrometric detection.A novel RP zirconia-based stationary phase with deactivated Lewis acid sites of zirconia was introduced to enable the use of volatile additives (acetate, formate) despite their low Lewis basicity. It is reported on the influence of surface deactivationon chromatographic behaviour of acidic, basic and neutral analytes in this paper. The influence of variables such as pH levels, Lewis base type, its concentration and temperature were studied. The results were compared with the undeactiva
Název v anglickém jazyce
The Retention Behavior of Acidic, Basic and Neutral Pharmaceuticals on the Deactivated Polybutadiene Zirconia Phase
Popis výsledku anglicky
Reversed zirconia-based stationary phases belong among interesting alternatives of widely used RP silica phases. Zirconia displays specific surface properties, which are responsible for a unique retention mechanism. Furthermore, especially for acidic analytes it is necessary to add a strong Lewis base to the mobile phase mainly to improve the separation efficiency. However, commonly recommended strong Lewis base buffers are not volatile and therefore are incompatible with a mass spectrometric detection.A novel RP zirconia-based stationary phase with deactivated Lewis acid sites of zirconia was introduced to enable the use of volatile additives (acetate, formate) despite their low Lewis basicity. It is reported on the influence of surface deactivationon chromatographic behaviour of acidic, basic and neutral analytes in this paper. The influence of variables such as pH levels, Lewis base type, its concentration and temperature were studied. The results were compared with the undeactiva
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CB - Analytická chemie, separace
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current Analytical Chemistry
ISSN
1573-4110
e-ISSN
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Svazek periodika
8
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
AE - Spojené arabské emiráty
Počet stran výsledku
9
Strana od-do
574-582
Kód UT WoS článku
000308673900018
EID výsledku v databázi Scopus
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