High active potential antimycobacterial agents against Mycobacterium avium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10125130" target="_blank" >RIV/00216208:11160/12:10125130 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.prolekare.cz/ceska-slovenska-farmacie-clanek/vysoce-ucinne-potencialni-antimykobakterialni-latky-proti-em-mycobacterium-avium-em-38561" target="_blank" >http://www.prolekare.cz/ceska-slovenska-farmacie-clanek/vysoce-ucinne-potencialni-antimykobakterialni-latky-proti-em-mycobacterium-avium-em-38561</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

High active potential antimycobacterial agents against Mycobacterium avium

Popis výsledku v původním jazyce

Derivatives of 3-phenyl-2H-1,3-benzoxazme-2,4(3H)- -dione are active against Mycobacterium avium when substituted in position 7 with a methyl. One or two carbonyl groups have to be replaced with a thioxo group. High active derivatives are the compounds without substitution on the phenyl, or those substituted on the phenyl in position 3 or 4 with chlorine, bromine or a methyl. The substitution in position 3 and 4 with two atoms of chlorine lowers the activity. The compounds are active against INH resistant strains. We synthesized other 44 derivatives with a similar structure of the compounds as in the paper but substituted in position 7 with other substituents (chlorine, bromine methoxy). The activity against M. avium was poor. It can be concluded thata new group of compounds with an excellent activity against M. avium has been found.

Název v anglickém jazyce

High active potential antimycobacterial agents against Mycobacterium avium

Popis výsledku anglicky

Derivatives of 3-phenyl-2H-1,3-benzoxazme-2,4(3H)- -dione are active against Mycobacterium avium when substituted in position 7 with a methyl. One or two carbonyl groups have to be replaced with a thioxo group. High active derivatives are the compounds without substitution on the phenyl, or those substituted on the phenyl in position 3 or 4 with chlorine, bromine or a methyl. The substitution in position 3 and 4 with two atoms of chlorine lowers the activity. The compounds are active against INH resistant strains. We synthesized other 44 derivatives with a similar structure of the compounds as in the paper but substituted in position 7 with other substituents (chlorine, bromine methoxy). The activity against M. avium was poor. It can be concluded thata new group of compounds with an excellent activity against M. avium has been found.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Svazek periodika

61

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

127-129

Kód UT WoS článku

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EID výsledku v databázi Scopus

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