Simultaneous Determination of Propranolol Hydrochloride and Sodium Benzoate in Oral Liquid Preparations by HPLC

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145626" target="_blank" >RIV/00216208:11160/13:10145626 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/13:10145626

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s10337-013-2457-z/fulltext.html" target="_blank" >http://link.springer.com/article/10.1007/s10337-013-2457-z/fulltext.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-013-2457-z" target="_blank" >10.1007/s10337-013-2457-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Simultaneous Determination of Propranolol Hydrochloride and Sodium Benzoate in Oral Liquid Preparations by HPLC

Popis výsledku v původním jazyce

A simple, selective and sensitive HPLC-UV method for quantification of propranolol hydrochloride and sodium benzoate in oral liquid preparations was developed and fully validated. Separation was performed by Supelco Discovery(A (R)) C18 (25 cm x 4.6 mm,particles 5 mu m) column. UV/VIS absorbance detector was set at wavelength 230 nm. Column oven was conditioned to 25 A degrees C. Mobile phase was prepared by dissolving 1.6 g of sodium dodecyl sulphate and 0.31 g of tetrabutylammonium dihydrogen phosphate in 450 mL of ultrapure water; 1 mL of sulphuric acid (95-97 %) and 550 mL of acetonitrile were added. Sodium hydroxide solution (2.1 M) was used for adjusting pH to value 3.3 (+/- 0.05). Retention times of sodium benzoate, propranolol hydrochloride and butylparaben (internal standard) were 2.2, 3.3 and 4.1 min, respectively. Newly developed method is suitable for simultaneous determination of propranolol hydrochloride and sodium benzoate in oral liquid preparations which are used for

Název v anglickém jazyce

Simultaneous Determination of Propranolol Hydrochloride and Sodium Benzoate in Oral Liquid Preparations by HPLC

Popis výsledku anglicky

A simple, selective and sensitive HPLC-UV method for quantification of propranolol hydrochloride and sodium benzoate in oral liquid preparations was developed and fully validated. Separation was performed by Supelco Discovery(A (R)) C18 (25 cm x 4.6 mm,particles 5 mu m) column. UV/VIS absorbance detector was set at wavelength 230 nm. Column oven was conditioned to 25 A degrees C. Mobile phase was prepared by dissolving 1.6 g of sodium dodecyl sulphate and 0.31 g of tetrabutylammonium dihydrogen phosphate in 450 mL of ultrapure water; 1 mL of sulphuric acid (95-97 %) and 550 mL of acetonitrile were added. Sodium hydroxide solution (2.1 M) was used for adjusting pH to value 3.3 (+/- 0.05). Retention times of sodium benzoate, propranolol hydrochloride and butylparaben (internal standard) were 2.2, 3.3 and 4.1 min, respectively. Newly developed method is suitable for simultaneous determination of propranolol hydrochloride and sodium benzoate in oral liquid preparations which are used for

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/EE2.3.20.0235" target="_blank" >EE2.3.20.0235: Vybudování výzkumného týmu experimentální a aplikované biofarmacie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chromatographia

ISSN

0009-5893

e-ISSN

—

Svazek periodika

76

Číslo periodika v rámci svazku

21-22

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

1553-1558

Kód UT WoS článku

000326118900017

EID výsledku v databázi Scopus

—