A review of complementary separation methods and matrix assisted laser desorption ionization-mass spectrometry imaging: Lowering sample complexity
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145825" target="_blank" >RIV/00216208:11160/13:10145825 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.sciencedirect.com/science/article/pii/S0021967313016270" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0021967313016270</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chroma.2013.10.027" target="_blank" >10.1016/j.chroma.2013.10.027</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A review of complementary separation methods and matrix assisted laser desorption ionization-mass spectrometry imaging: Lowering sample complexity
Popis výsledku v původním jazyce
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) brings unique combined information on molecular identity and molecular distribution of a sample surface. During the past decade, it has matured and is now routinely employed for biomedical tissue sections analysis. However, owing to the high molecular complexity of tissue, MALDI-MSI suffers from ionization suppression effects. This directly results in a reduced ability to detect low-abundant molecular species. At the same time, the spatial resolution of separation techniques can be insufficient for an unambiguous determination of the local composition of a mixture. As analytical separation techniques can significantly reduce ion suppression, and MALDI-MSI has an abilityto improve their spatial resolution, the two analytical approaches can successfully be combined in a pursuit of comprehensive local sample composition information. In the following review we summarize strategies of mutually beneficial co
Název v anglickém jazyce
A review of complementary separation methods and matrix assisted laser desorption ionization-mass spectrometry imaging: Lowering sample complexity
Popis výsledku anglicky
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) brings unique combined information on molecular identity and molecular distribution of a sample surface. During the past decade, it has matured and is now routinely employed for biomedical tissue sections analysis. However, owing to the high molecular complexity of tissue, MALDI-MSI suffers from ionization suppression effects. This directly results in a reduced ability to detect low-abundant molecular species. At the same time, the spatial resolution of separation techniques can be insufficient for an unambiguous determination of the local composition of a mixture. As analytical separation techniques can significantly reduce ion suppression, and MALDI-MSI has an abilityto improve their spatial resolution, the two analytical approaches can successfully be combined in a pursuit of comprehensive local sample composition information. In the following review we summarize strategies of mutually beneficial co
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CB - Analytická chemie, separace
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Chromatography A
ISSN
0021-9673
e-ISSN
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Svazek periodika
1319
Číslo periodika v rámci svazku
December
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
13
Strana od-do
1-13
Kód UT WoS článku
000327570200001
EID výsledku v databázi Scopus
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