Endoglin is not expressed with cell adhesion molecules in aorta during atherogenesis in apoE-deficient mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312686" target="_blank" >RIV/00216208:11160/15:10312686 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.hh.um.es/Abstracts/Vol_30/30_2/30_2_233.htm" target="_blank" >http://www.hh.um.es/Abstracts/Vol_30/30_2/30_2_233.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14670/HH-30.233" target="_blank" >10.14670/HH-30.233</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endoglin is not expressed with cell adhesion molecules in aorta during atherogenesis in apoE-deficient mice

Popis výsledku v původním jazyce

Endoglin (TGF-beta receptor III), has been demonstrated to affect vascular endothelium and atherosclerosis. Moreover, it was also demonstrated that endoglin is involved in inflammation and plays a role in leukocyte adhesion and transmigration in vitro and in vivo but not in atherosclerosis related vessels. In this study, we wanted to evaluate endoglin expression in two different parts of the aorta (heart aortic sinus and ascending aorta) and assess its potential simultaneous expression with cell adhesion molecules in non-atherosclerotic and atherosclerotic aortas of apoE-deficient mice. Ten-week-old female apolipoprotein E-deficient mice on a C57BL/6J background (n=24) were randomly subdivided into three groups and were fed either chow diet (for another two months) or Western type diet (for another two or four months). Immunohistochemical staining of endoglin, VCAM-1 and P-selectin in aortic sinus and ascending aorta was performed. Endoglin expression was detected only in endothelial c

Název v anglickém jazyce

Endoglin is not expressed with cell adhesion molecules in aorta during atherogenesis in apoE-deficient mice

Popis výsledku anglicky

Endoglin (TGF-beta receptor III), has been demonstrated to affect vascular endothelium and atherosclerosis. Moreover, it was also demonstrated that endoglin is involved in inflammation and plays a role in leukocyte adhesion and transmigration in vitro and in vivo but not in atherosclerosis related vessels. In this study, we wanted to evaluate endoglin expression in two different parts of the aorta (heart aortic sinus and ascending aorta) and assess its potential simultaneous expression with cell adhesion molecules in non-atherosclerotic and atherosclerotic aortas of apoE-deficient mice. Ten-week-old female apolipoprotein E-deficient mice on a C57BL/6J background (n=24) were randomly subdivided into three groups and were fed either chow diet (for another two months) or Western type diet (for another two or four months). Immunohistochemical staining of endoglin, VCAM-1 and P-selectin in aortic sinus and ascending aorta was performed. Endoglin expression was detected only in endothelial c

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Zvýšení kapacity vědecko-výzkumných týmů Univerzity Karlovy prostřednictvím nových pozic pro absolventy doktorandských studií</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Histology and Histopathology

ISSN

0213-3911

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

12

Strana od-do

233-244

Kód UT WoS článku

000351201300011

EID výsledku v databázi Scopus

2-s2.0-84920945088