The Aryl Hydrocarbon Receptor in the Human Placental Trophoblast: The Impact of Nutraceuticals and Natural Products
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312787" target="_blank" >RIV/00216208:11160/15:10312787 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.crcnetbase.com/doi/10.1201/b19151-28" target="_blank" >http://www.crcnetbase.com/doi/10.1201/b19151-28</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1201/b19151-28" target="_blank" >10.1201/b19151-28</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Aryl Hydrocarbon Receptor in the Human Placental Trophoblast: The Impact of Nutraceuticals and Natural Products
Popis výsledku v původním jazyce
The aryl hydrocarbon receptor (AHR) and its heterodimer AHR nuclear translocator (ARNT) form a ligand-activated transcription complex that regulates the expression of numerous target genes involved in the biotransformation of both xenobiotic and endogenous compounds, including cytochrome P450 enzymes CYP1A1, CYP1A2, and CYP1B1; glutathione S-transferase GST1; UDP-glucuronosyltransferases UGT1A1 and UGT1A6; NAD(P)H-dependent quinone dehydrogenase NQO1; aldehyde dehydrogenase ALDH3A1; and breast cancer resistance protein. Placental expression, as well as the ontogeny of AHR, has been recently described both in human or rat placenta, and the regulation of its target genes has been studied in the placental trophoblast. Interestingly, of the AHR target genes, only cytochrome P450 CYP1A1 has been found to be significantly inducible in the human placental trophoblast, with significant enzymatic activities having been described. Herein, we summarize recent findings related to the toxicological
Název v anglickém jazyce
The Aryl Hydrocarbon Receptor in the Human Placental Trophoblast: The Impact of Nutraceuticals and Natural Products
Popis výsledku anglicky
The aryl hydrocarbon receptor (AHR) and its heterodimer AHR nuclear translocator (ARNT) form a ligand-activated transcription complex that regulates the expression of numerous target genes involved in the biotransformation of both xenobiotic and endogenous compounds, including cytochrome P450 enzymes CYP1A1, CYP1A2, and CYP1B1; glutathione S-transferase GST1; UDP-glucuronosyltransferases UGT1A1 and UGT1A6; NAD(P)H-dependent quinone dehydrogenase NQO1; aldehyde dehydrogenase ALDH3A1; and breast cancer resistance protein. Placental expression, as well as the ontogeny of AHR, has been recently described both in human or rat placenta, and the regulation of its target genes has been studied in the placental trophoblast. Interestingly, of the AHR target genes, only cytochrome P450 CYP1A1 has been found to be significantly inducible in the human placental trophoblast, with significant enzymatic activities having been described. Herein, we summarize recent findings related to the toxicological
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centrum interakcí potravních doplňků s léčivy a nutrigenetiky</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Human Placental Trophoblasts : Impact of Maternal Nutrition
ISBN
978-1-4822-5428-0
Počet stran výsledku
16
Strana od-do
329-344
Počet stran knihy
426
Název nakladatele
CRC Press
Místo vydání
Boca Raton
Kód UT WoS kapitoly
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