Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33145267" target="_blank" >RIV/61989592:15310/13:33145267 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/13:10145998 RIV/61989592:15110/13:33145267

Výsledek na webu

<a href="http://dx.doi.org/10.2478/v10136-012-0022-y" target="_blank" >http://dx.doi.org/10.2478/v10136-012-0022-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10136-012-0022-y" target="_blank" >10.2478/v10136-012-0022-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast

Popis výsledku v původním jazyce

Antenatal glucocorticoid administration is used in cases of fetuses at risk to be born prematurely to enhance fetal pulmonary surfactant production and prevent infant respiratory distress syndrome. The CYP1A1 is the most important xenobiotic-metabolizingcytochrome P450 enzyme in the human placenta. Importantly, CYP1A1 generates reactive species and its placental activity is elevated in smoking women. CYP1A1 expression is mainly controlled by aryl hydrocarbon receptor (AHR) ligands. Glucocorticoid co-regulation of CYP1A1 has been described in various cell types but has not been systematically examined in the human placental trophoblast. We studied the effects of the glucocorticoids dexamethasone and betamethasone on inducibility of CYP1A1 and other AHRtarget genes CYP1A2, CYP1B1, UGT1A1 (UDP-glucuronosyltransferase 1A1) and BCRP (Breast cancer resistance protein) by prototype AHR ligand -methylcholanthrene (3MC) in isolated human placental trophoblast culture. We show that glucocortic

Název v anglickém jazyce

Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast

Popis výsledku anglicky

Antenatal glucocorticoid administration is used in cases of fetuses at risk to be born prematurely to enhance fetal pulmonary surfactant production and prevent infant respiratory distress syndrome. The CYP1A1 is the most important xenobiotic-metabolizingcytochrome P450 enzyme in the human placenta. Importantly, CYP1A1 generates reactive species and its placental activity is elevated in smoking women. CYP1A1 expression is mainly controlled by aryl hydrocarbon receptor (AHR) ligands. Glucocorticoid co-regulation of CYP1A1 has been described in various cell types but has not been systematically examined in the human placental trophoblast. We studied the effects of the glucocorticoids dexamethasone and betamethasone on inducibility of CYP1A1 and other AHRtarget genes CYP1A2, CYP1B1, UGT1A1 (UDP-glucuronosyltransferase 1A1) and BCRP (Breast cancer resistance protein) by prototype AHR ligand -methylcholanthrene (3MC) in isolated human placental trophoblast culture. We show that glucocortic

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

163-172

Kód UT WoS článku

000315854000005

EID výsledku v databázi Scopus

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