Synthesis of a molecularly imprinted sorbent for selective solid-phase extraction of beta-N-methylamino-L-alanine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312832" target="_blank" >RIV/00216208:11160/15:10312832 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0039914015301806" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039914015301806</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.talanta.2015.07.052" target="_blank" >10.1016/j.talanta.2015.07.052</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of a molecularly imprinted sorbent for selective solid-phase extraction of beta-N-methylamino-L-alanine

Popis výsledku v původním jazyce

The aim of the work was to synthesize a molecularly imprinted material for the selective solid-phase extraction (SPE) of beta-N-methylamino-L-alanine (L-2-amino-3-methylpropionic acid; BMAA) from cyanobacterial extracts. BMAA and its structural analogs that can be used as template are small, polar and hydrophilic molecules. These molecules are poorly soluble in organic solvents that are commonly used for the synthesis of acrylic-based polymers. Therefore, a sol gel approach was chosen to carry out the synthesis and the resulting sorbents were evaluated with different extraction procedures in order to determine their ability to selectively retain BMAA. The presence of imprinted cavities in the sorbent was demonstrated by comparing elution profiles obtained by using molecularly imprinted silica (MIS) and non-imprinted silica (NIS) as a control. The molecularly imprinted solid-phase extraction (MISPE) procedure was first developed in a pure medium (acetonitrile) and further optimized for

Název v anglickém jazyce

Synthesis of a molecularly imprinted sorbent for selective solid-phase extraction of beta-N-methylamino-L-alanine

Popis výsledku anglicky

The aim of the work was to synthesize a molecularly imprinted material for the selective solid-phase extraction (SPE) of beta-N-methylamino-L-alanine (L-2-amino-3-methylpropionic acid; BMAA) from cyanobacterial extracts. BMAA and its structural analogs that can be used as template are small, polar and hydrophilic molecules. These molecules are poorly soluble in organic solvents that are commonly used for the synthesis of acrylic-based polymers. Therefore, a sol gel approach was chosen to carry out the synthesis and the resulting sorbents were evaluated with different extraction procedures in order to determine their ability to selectively retain BMAA. The presence of imprinted cavities in the sorbent was demonstrated by comparing elution profiles obtained by using molecularly imprinted silica (MIS) and non-imprinted silica (NIS) as a control. The molecularly imprinted solid-phase extraction (MISPE) procedure was first developed in a pure medium (acetonitrile) and further optimized for

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Talanta

ISSN

0039-9140

e-ISSN

—

Svazek periodika

144

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1021-1029

Kód UT WoS článku

000363346200139

EID výsledku v databázi Scopus

2-s2.0-84938630035