Mandelic acid derived ionic liquids: synthesis, toxicity and biodegradability

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10364662" target="_blank" >RIV/00216208:11160/17:10364662 - isvavai.cz</a>

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra25562k" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra25562k</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6ra25562k" target="_blank" >10.1039/c6ra25562k</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mandelic acid derived ionic liquids: synthesis, toxicity and biodegradability

Popis výsledku v původním jazyce

A series of ten ionic liquids (ILs) was synthesised from the renewable resource mandelic acid. The ILs showed low antimicrobial activity towards the thirteen bacterial and twelve fungal strains they were screened against. A general trend of increasing bacterial toxicity in the order methyl ester &lt; ethyl ester &lt; n-butyl ester/amide was observed. IL biodegradability was evaluated using the Closed Bottle test (OECD 301D). Biodegradation increased in the order of increasing alkyl chain length for the ester ILs (methyl &lt; ethyl &lt; n-butyl). Despite none of the ILs presenting as readily biodegradable (&gt; 60% in 28 days), a series of biodegradation transformation products has been proposed based on the degradation of the ester/amide alkyl chain. This data has allowed for an assessment of the effect of IL structural features on toxicity and biodegradation, particularly allowing for a comparison to earlier work where additional oxygen atoms were present to facilitate biodegradation and attenuate toxicity. The mandelic acid derived ILs did not pass the Closed Bottle test (OECD 301D) and can be included in the rules of thumb for the design of biodegradable ILs.

Název v anglickém jazyce

Mandelic acid derived ionic liquids: synthesis, toxicity and biodegradability

Popis výsledku anglicky

A series of ten ionic liquids (ILs) was synthesised from the renewable resource mandelic acid. The ILs showed low antimicrobial activity towards the thirteen bacterial and twelve fungal strains they were screened against. A general trend of increasing bacterial toxicity in the order methyl ester &lt; ethyl ester &lt; n-butyl ester/amide was observed. IL biodegradability was evaluated using the Closed Bottle test (OECD 301D). Biodegradation increased in the order of increasing alkyl chain length for the ester ILs (methyl &lt; ethyl &lt; n-butyl). Despite none of the ILs presenting as readily biodegradable (&gt; 60% in 28 days), a series of biodegradation transformation products has been proposed based on the degradation of the ester/amide alkyl chain. This data has allowed for an assessment of the effect of IL structural features on toxicity and biodegradation, particularly allowing for a comparison to earlier work where additional oxygen atoms were present to facilitate biodegradation and attenuate toxicity. The mandelic acid derived ILs did not pass the Closed Bottle test (OECD 301D) and can be included in the rules of thumb for the design of biodegradable ILs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/GA15-07332S" target="_blank" >GA15-07332S: Přírodní laktony a laktamy: Účelné syntetické variace vedoucí k rozmanitým biologických aktivitám</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

2115-2126

Kód UT WoS článku

000393748000044

EID výsledku v databázi Scopus

2-s2.0-85009476044