The effects of bisphenols on the cardiovascular system ex vivo and in vivo

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F23%3A10471056" target="_blank" >RIV/00216208:11160/23:10471056 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=96RUm1amcZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=96RUm1amcZ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chemosphere.2022.137565" target="_blank" >10.1016/j.chemosphere.2022.137565</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effects of bisphenols on the cardiovascular system ex vivo and in vivo

Popis výsledku v původním jazyce

Humans are commonly and regularly exposed to bisphenols, but their cardiovascular effects were ambiguous or not know due to absence of studies. The aim of this study was to test 14 bisphenols (A, AF, AP, B, BP, C, E, F, G, M, P, PH, S and Z), and compare their effects in vitro (human and rat cell lines), ex vivo (isolated rat aorta) and in vivo (Wistar Han rats, acutely or chronically exposed to low environmental and high toxic doses). The majority of the tested bisphenols relaxed rat aorta, but their potency varied markedly. The mechanism of action was likely based on the inhibition of calcium influx via L-type calcium channels. The cytotoxicity of bisphenols towards cell lines showed variable potencies. The in vivo acute effects of three doses (0.005, 0.05 and 2.5 mg/kg) of bisphenol AF and 3 other analogues (A, S and F) on the cardiovascular system were, however, rather biologically negligible. The most potent bisphenol, AF, administered chronically had also no impact on arterial blood pressure.

Název v anglickém jazyce

The effects of bisphenols on the cardiovascular system ex vivo and in vivo

Popis výsledku anglicky

Humans are commonly and regularly exposed to bisphenols, but their cardiovascular effects were ambiguous or not know due to absence of studies. The aim of this study was to test 14 bisphenols (A, AF, AP, B, BP, C, E, F, G, M, P, PH, S and Z), and compare their effects in vitro (human and rat cell lines), ex vivo (isolated rat aorta) and in vivo (Wistar Han rats, acutely or chronically exposed to low environmental and high toxic doses). The majority of the tested bisphenols relaxed rat aorta, but their potency varied markedly. The mechanism of action was likely based on the inhibition of calcium influx via L-type calcium channels. The cytotoxicity of bisphenols towards cell lines showed variable potencies. The in vivo acute effects of three doses (0.005, 0.05 and 2.5 mg/kg) of bisphenol AF and 3 other analogues (A, S and F) on the cardiovascular system were, however, rather biologically negligible. The most potent bisphenol, AF, administered chronically had also no impact on arterial blood pressure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemosphere

ISSN

0045-6535

e-ISSN

1879-1298

Svazek periodika

313

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

137565

Kód UT WoS článku

000904035100005

EID výsledku v databázi Scopus

2-s2.0-85144408457