Long-term exposure to very low doses of bisphenol S affects female reproduction
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A76948" target="_blank" >RIV/60460709:41210/18:76948 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11140/18:10375514 RIV/00027014:_____/18:N0000111
Výsledek na webu
<a href="http://dx.doi.org/10.1530/REP-18-0092" target="_blank" >http://dx.doi.org/10.1530/REP-18-0092</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/REP-18-0092" target="_blank" >10.1530/REP-18-0092</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Long-term exposure to very low doses of bisphenol S affects female reproduction
Popis výsledku v původním jazyce
Bisphenols belong to the endocrine disruptors, affecting reproduction even in extremely low doses. Bisphenol S (BPS) has become widely used as a substitute for the earlier-used bisphenol A, however, its harmlessness is questionable. The aim of this study was to evaluate the effect of BPS on folliculogenesis and oocyte quality after in vivo exposure to low doses of BPS. Four-week-old ICR females were exposed to vehicle control, BPS1, BPS2, BPS3 and BPS4 for 4 weeks. Ovaries were subjected to stereology and nano liquid chromatography-mass spectrometry. Simultaneously, metaphase II oocytes were obtained after pregnant mare serum gonadotrophin and human chorionic gonadotrophin administration, followed by immunostaining. In particular, mating and two-cell embryo flushing were performed. We observed that BPS decreases the amount of ovarian follicles and BPS2 affects the volume of antral follicles. Accordingly, ovarian proteome is affected after BPS2 treatment. While BPS2 dosing results mainly in cytoskelet
Název v anglickém jazyce
Long-term exposure to very low doses of bisphenol S affects female reproduction
Popis výsledku anglicky
Bisphenols belong to the endocrine disruptors, affecting reproduction even in extremely low doses. Bisphenol S (BPS) has become widely used as a substitute for the earlier-used bisphenol A, however, its harmlessness is questionable. The aim of this study was to evaluate the effect of BPS on folliculogenesis and oocyte quality after in vivo exposure to low doses of BPS. Four-week-old ICR females were exposed to vehicle control, BPS1, BPS2, BPS3 and BPS4 for 4 weeks. Ovaries were subjected to stereology and nano liquid chromatography-mass spectrometry. Simultaneously, metaphase II oocytes were obtained after pregnant mare serum gonadotrophin and human chorionic gonadotrophin administration, followed by immunostaining. In particular, mating and two-cell embryo flushing were performed. We observed that BPS decreases the amount of ovarian follicles and BPS2 affects the volume of antral follicles. Accordingly, ovarian proteome is affected after BPS2 treatment. While BPS2 dosing results mainly in cytoskelet
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
40301 - Veterinary science
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
REPRODUCTION
ISSN
1470-1626
e-ISSN
1741-7899
Svazek periodika
156
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
11
Strana od-do
47-57
Kód UT WoS článku
000440011400013
EID výsledku v databázi Scopus
2-s2.0-85049623395