A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10504976" target="_blank" >RIV/00216208:11160/25:10504976 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=k36Iby-J9o" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=k36Iby-J9o</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envint.2025.109738" target="_blank" >10.1016/j.envint.2025.109738</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition

Popis výsledku v původním jazyce

Bisphenols have been recognized as environmental pollutants. Bans on bisphenol A use led to the replacement by alternatives. There are, however, almost no data on their biological effects. This study has focused on the potential negative impact of four alternatives to bisphenol A on haemostasis and erythrocytes. The erythrocyte toxicity of all tested compounds was relatively low, with TC50s above 500 microM in all cases. None of the compounds augmented platelet aggregation, but DD-70 was a potent antiplatelet compound with an IC50 of 5.0 +/- 2.7 microM in arachidonic acid-triggered platelet aggregation. DD-70 also blocked other aggregation pathways, and its mechanism was primarily based on the inhibition of cyclooxygenase 1. Only high concentrations of the tested bisphenol A alternatives (&gt;= 100 microM) influenced blood coagulation.

Název v anglickém jazyce

A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition

Popis výsledku anglicky

Bisphenols have been recognized as environmental pollutants. Bans on bisphenol A use led to the replacement by alternatives. There are, however, almost no data on their biological effects. This study has focused on the potential negative impact of four alternatives to bisphenol A on haemostasis and erythrocytes. The erythrocyte toxicity of all tested compounds was relatively low, with TC50s above 500 microM in all cases. None of the compounds augmented platelet aggregation, but DD-70 was a potent antiplatelet compound with an IC50 of 5.0 +/- 2.7 microM in arachidonic acid-triggered platelet aggregation. DD-70 also blocked other aggregation pathways, and its mechanism was primarily based on the inhibition of cyclooxygenase 1. Only high concentrations of the tested bisphenol A alternatives (&gt;= 100 microM) influenced blood coagulation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GF24-12943K" target="_blank" >GF24-12943K: Náhrady bisfenolu A: zdravotní rizika ve vztahu k endokrinnímu a kardiovaskulárnímu systému</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environment International

ISSN

0160-4120

e-ISSN

1873-6750

Svazek periodika

203

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

109738

Kód UT WoS článku

001563970900005

EID výsledku v databázi Scopus

2-s2.0-105014294878