Chitosan- and levan-based wound dressings crosslinked with dialdehyde levan: Structural and biological stability under climatic aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10505434" target="_blank" >RIV/00216208:11160/25:10505434 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3jrxCQskaN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3jrxCQskaN</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2025.146207" target="_blank" >10.1016/j.ijbiomac.2025.146207</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chitosan- and levan-based wound dressings crosslinked with dialdehyde levan: Structural and biological stability under climatic aging

Popis výsledku v původním jazyce

Wounds are a global health challenge that often causes serious consequences in terms of morbidity or mortality. However, good wound dressings should retain their properties for an adequate period to avoid risking the health and lives of patients. Therefore, in this study, we first compared the long-term stability and biological performance of two polysaccharide-based sponges-chitosan- and levan-based-crosslinked with dialdehyde levan synthesized by our team. The composites were stored in a climatic chamber for six months under constant temperature and humidity conditions. After each month, a series of analyses characterizing the physicochemical and biological properties of the composite were performed, evaluating their usefulness for their potential use as wound dressing materials. The results showed that the levan-based sponge maintained its structure for up to 4 months of storage in the climate chamber, while the chitosan-based sponge retained its structure throughout the study period. A slight decrease in physicochemical and biological properties was observed in both cases during this time. However, this decrease did not affect the proper functioning of the composites, suggesting that both materials remain viable for use in wound healing applications. Notably, chitosan-based sponges showed superior long-term stability, making them a more reliable material for extended wound dressing applications.

Název v anglickém jazyce

Chitosan- and levan-based wound dressings crosslinked with dialdehyde levan: Structural and biological stability under climatic aging

Popis výsledku anglicky

Wounds are a global health challenge that often causes serious consequences in terms of morbidity or mortality. However, good wound dressings should retain their properties for an adequate period to avoid risking the health and lives of patients. Therefore, in this study, we first compared the long-term stability and biological performance of two polysaccharide-based sponges-chitosan- and levan-based-crosslinked with dialdehyde levan synthesized by our team. The composites were stored in a climatic chamber for six months under constant temperature and humidity conditions. After each month, a series of analyses characterizing the physicochemical and biological properties of the composite were performed, evaluating their usefulness for their potential use as wound dressing materials. The results showed that the levan-based sponge maintained its structure for up to 4 months of storage in the climate chamber, while the chitosan-based sponge retained its structure throughout the study period. A slight decrease in physicochemical and biological properties was observed in both cases during this time. However, this decrease did not affect the proper functioning of the composites, suggesting that both materials remain viable for use in wound healing applications. Notably, chitosan-based sponges showed superior long-term stability, making them a more reliable material for extended wound dressing applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

1879-0003

Svazek periodika

321

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

18

Strana od-do

146207

Kód UT WoS článku

001540522800006

EID výsledku v databázi Scopus

2-s2.0-105011167583