Magnesium sulfate in oxidative stress-associated pathologies: clinical, cellular, and molecular perspectives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10515325" target="_blank" >RIV/00216208:11160/25:10515325 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kezUM_JVe-" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kezUM_JVe-</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12551-025-01292-z" target="_blank" >10.1007/s12551-025-01292-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnesium sulfate in oxidative stress-associated pathologies: clinical, cellular, and molecular perspectives

Popis výsledku v původním jazyce

Magnesium sulfate (MgSO4) is a therapeutically versatile agent used across various medical conditions. This review integrates experimental and computational findings to elucidate the clinical, cellular, molecular, and electronic mechanisms underlying MgSO4&apos;s therapeutic effects, focusing on its antioxidant properties. MgSO4 remains the gold standard treatment for preeclampsia and eclampsia, preventing seizures and mitigating oxidative damage. In preterm birth, it offers fetal neuroprotection, although its efficacy as a tocolytic agent is limited. MgSO4 also shows promise in treating respiratory conditions, notably severe asthma, where it acts as a bronchodilator. Its applications extend to anesthesia, pain management, and cardiac arrhythmias, reflecting its diverse pharmacological actions. Advanced computational methods, including molecular dynamics simulations and quantum chemistry calculations, have revealed how MgSO4 interacts with cell membranes and neutralizes hydroxyl radicals. These studies suggest that MgSO4&apos;s antioxidant effects stem from its ability to stabilize membrane structures and modulate electron transfer processes. The therapeutic effects are mediated through multiple pathways, including calcium channel modulation, NMDA receptor antagonism, and anti-inflammatory mechanisms. Although generally safe, MgSO4 requires careful monitoring due to its narrow therapeutic window. Future research should focus on precision dosing strategies, innovative delivery systems, and expanded therapeutic applications. A comprehensive understanding of MgSO4&apos;s molecular mechanisms and clinical applications will further optimize its therapeutic use.

Název v anglickém jazyce

Magnesium sulfate in oxidative stress-associated pathologies: clinical, cellular, and molecular perspectives

Popis výsledku anglicky

Magnesium sulfate (MgSO4) is a therapeutically versatile agent used across various medical conditions. This review integrates experimental and computational findings to elucidate the clinical, cellular, molecular, and electronic mechanisms underlying MgSO4&apos;s therapeutic effects, focusing on its antioxidant properties. MgSO4 remains the gold standard treatment for preeclampsia and eclampsia, preventing seizures and mitigating oxidative damage. In preterm birth, it offers fetal neuroprotection, although its efficacy as a tocolytic agent is limited. MgSO4 also shows promise in treating respiratory conditions, notably severe asthma, where it acts as a bronchodilator. Its applications extend to anesthesia, pain management, and cardiac arrhythmias, reflecting its diverse pharmacological actions. Advanced computational methods, including molecular dynamics simulations and quantum chemistry calculations, have revealed how MgSO4 interacts with cell membranes and neutralizes hydroxyl radicals. These studies suggest that MgSO4&apos;s antioxidant effects stem from its ability to stabilize membrane structures and modulate electron transfer processes. The therapeutic effects are mediated through multiple pathways, including calcium channel modulation, NMDA receptor antagonism, and anti-inflammatory mechanisms. Although generally safe, MgSO4 requires careful monitoring due to its narrow therapeutic window. Future research should focus on precision dosing strategies, innovative delivery systems, and expanded therapeutic applications. A comprehensive understanding of MgSO4&apos;s molecular mechanisms and clinical applications will further optimize its therapeutic use.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biophysical Reviews

ISSN

1867-2450

e-ISSN

1867-2469

Svazek periodika

17

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

25

Strana od-do

511-535

Kód UT WoS článku

001434522800001

EID výsledku v databázi Scopus

2-s2.0-85219015667