New light on an old friend: targeting PUMA in radioprotection and therapy of cardiovascular and neurodegenerative diseases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889712" target="_blank" >RIV/60162694:G44__/18:43889712 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00179906:_____/18:10385041 RIV/00216208:11150/18:10385041
Výsledek na webu
<a href="http://www.eurekaselect.com/161074/article" target="_blank" >http://www.eurekaselect.com/161074/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389450119666180406110743" target="_blank" >10.2174/1389450119666180406110743</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
New light on an old friend: targeting PUMA in radioprotection and therapy of cardiovascular and neurodegenerative diseases
Popis výsledku v původním jazyce
This review summarizes recent progress in understanding the role of p53-upregulated mediator of apoptosis (PUMA) in molecular pathways with respect to its potential therapeutic applications. Particular emphasis is given to the PUMA's role in ionizing radiation-induced signalling as radiotoxicity of normal tissue is mediated mostly via apoptosis. PUMA and its p53-dependent and p53- independent induction are described and potential use as a new target for the development of radioprotective agents is suggested. Further implications, including targeting PUMA to prevent and treat cardiovascular and neurodegenerative diseases, are also discussed together with an overview of other therapeutic applications. Finally, basic chemical structures for the development of novel PUMA modulators such as pifithrine derivatives, kinase inhibitors or modulators of Bcl-2 protein family are described
Název v anglickém jazyce
New light on an old friend: targeting PUMA in radioprotection and therapy of cardiovascular and neurodegenerative diseases
Popis výsledku anglicky
This review summarizes recent progress in understanding the role of p53-upregulated mediator of apoptosis (PUMA) in molecular pathways with respect to its potential therapeutic applications. Particular emphasis is given to the PUMA's role in ionizing radiation-induced signalling as radiotoxicity of normal tissue is mediated mostly via apoptosis. PUMA and its p53-dependent and p53- independent induction are described and potential use as a new target for the development of radioprotective agents is suggested. Further implications, including targeting PUMA to prevent and treat cardiovascular and neurodegenerative diseases, are also discussed together with an overview of other therapeutic applications. Finally, basic chemical structures for the development of novel PUMA modulators such as pifithrine derivatives, kinase inhibitors or modulators of Bcl-2 protein family are described
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
<a href="/cs/project/GA17-13541S" target="_blank" >GA17-13541S: Vývoj nových radioprotektivních látek na bázi malých molekulárních inhibitorů</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current Drug Targets
ISSN
1389-4501
e-ISSN
—
Svazek periodika
19
Číslo periodika v rámci svazku
16
Stát vydavatele periodika
AE - Spojené arabské emiráty
Počet stran výsledku
15
Strana od-do
1943-1957
Kód UT WoS článku
000449269200007
EID výsledku v databázi Scopus
2-s2.0-85052623700