Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10000610" target="_blank" >RIV/00216208:11310/09:10000610 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/09:00334103

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti

Popis výsledku v původním jazyce

Sand flies transmit parasites of genus Leishmania, the causative agents of leishmaniases. Experimental hosts repeatedly exposed to sand fly saliva can control Leishmania infection. Cell-mediated anti-saliva immune response is most likely responsible forthis protective effect; however, there is no study concerning its antigenic specificity. In this study, splenocytes from mice exposed to Phlebotomus sergenti bites were challenged ex vivo with saliva from three different sand flies. Mice bitten by P. sergenti had higher proliferation to homologous antigen than splenocytes from naive mice. Splenocytes from P. sergenti bitten mice as well as anti-P. sergenti antibodies partially cross-reacted with P. papatasi saliva. In contrast, no crossreactivity was found with P. arabicus saliva. Our data indicate that both cellular and humoral immunity react in a species-specific manner and the unique transmission-blocking vaccine would be required for each vector ? Leishmania combination.

Název v anglickém jazyce

Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti

Popis výsledku anglicky

Sand flies transmit parasites of genus Leishmania, the causative agents of leishmaniases. Experimental hosts repeatedly exposed to sand fly saliva can control Leishmania infection. Cell-mediated anti-saliva immune response is most likely responsible forthis protective effect; however, there is no study concerning its antigenic specificity. In this study, splenocytes from mice exposed to Phlebotomus sergenti bites were challenged ex vivo with saliva from three different sand flies. Mice bitten by P. sergenti had higher proliferation to homologous antigen than splenocytes from naive mice. Splenocytes from P. sergenti bitten mice as well as anti-P. sergenti antibodies partially cross-reacted with P. papatasi saliva. In contrast, no crossreactivity was found with P. arabicus saliva. Our data indicate that both cellular and humoral immunity react in a species-specific manner and the unique transmission-blocking vaccine would be required for each vector ? Leishmania combination.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasite Immunology

ISSN

0141-9838

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000271469600005

EID výsledku v databázi Scopus

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