Quantitative Structure-Electrochemistry Relationship of 1-Phenyl- 5-benzyl-sulfanyltetrazoles and Their Electrooxidation as a Metabolic Model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10055298" target="_blank" >RIV/00216208:11310/10:10055298 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/10:00300532

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative Structure-Electrochemistry Relationship of 1-Phenyl- 5-benzyl-sulfanyltetrazoles and Their Electrooxidation as a Metabolic Model

Popis výsledku v původním jazyce

The quantitative structure-electrochemistry relationships study of nineteen derivatives of 1-phenyl-5-benzylsulfanyltetrazole, that seem to be very promising antimycobacterial drugs, resulted in a good correlation relationship between half-wave potentialand energy of HOMO orbital. The study of electrochemical oxidation of these compounds as a model of their possible metabolic degradation was performed. It was possible to propose a scheme of their electrochemical oxidation: the electrochemical oxidationstarts on the methoxy group, where by elimination of one electron the radical cation with very short life-time is formed. The free electron is translocated to the position 2, followed by closing of new cycle with -CH2- of benzylsulfanyl moiety. In the case of 2-methoxyphenyl tetrazoles this process is followed by the desintegration of the tetrazole ring.

Název v anglickém jazyce

Quantitative Structure-Electrochemistry Relationship of 1-Phenyl- 5-benzyl-sulfanyltetrazoles and Their Electrooxidation as a Metabolic Model

Popis výsledku anglicky

The quantitative structure-electrochemistry relationships study of nineteen derivatives of 1-phenyl-5-benzylsulfanyltetrazole, that seem to be very promising antimycobacterial drugs, resulted in a good correlation relationship between half-wave potentialand energy of HOMO orbital. The study of electrochemical oxidation of these compounds as a model of their possible metabolic degradation was performed. It was possible to propose a scheme of their electrochemical oxidation: the electrochemical oxidationstarts on the methoxy group, where by elimination of one electron the radical cation with very short life-time is formed. The free electron is translocated to the position 2, followed by closing of new cycle with -CH2- of benzylsulfanyl moiety. In the case of 2-methoxyphenyl tetrazoles this process is followed by the desintegration of the tetrazole ring.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electroanalysis

ISSN

1040-0397

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

17-18

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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